903568-75-2Relevant academic research and scientific papers
DUAL ACTION NITRIC OXIDE DONORS AND THEIR USE AS ANTIMICROBIAL AGENTS
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Page/Page column 49; 50, (2014/05/24)
The present invention relates generally to conjugates comprising a nitric oxide donor and an acyl homoserine lactone, fimbrolide, fimbrolide derivative, dihydropyrrolone or indole, and to the use of such conjugates as antimicrobial agents.
Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound
Chakrapani, Harinath,Goodblatt, Michael M.,Udupi, Vidya,Malaviya, Swati,Shami, Paul J.,Keefer, Larry K.,Saavedra, Joseph E.
, p. 950 - 953 (2008/09/20)
Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic
Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O 2-aryl diazeniumdiolates in vitro and in vivo
Shami, Paul J.,Saavedra, Joseph E.,Bonifant, Challice L.,Chu, Jingxi,Udupi, Vidya,Malaviya, Swati,Carr, Brian I.,Kar, Siddhartha,Wang, Meifeng,Jia, Lee,Ji, Xinhua,Keefer, Larry K.
, p. 4356 - 4366 (2008/04/18)
The literature provides evidence that metabolic nitric oxide (NO) release mediates the cytotoxic activities (against human leukemia and prostate cancer xenografts in mice) of JS-K, a compound of structure R2N-N(O)=NO-Ar for which R2N
