903587-20-2Relevant academic research and scientific papers
Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase
Maier, Jennifer A.,Brugel, Todd A.,Sabat, Mark,Golebiowski, Adam,Laufersweiler, Matthew J.,VanRens, John C.,Hopkins, Corey R.,De, Biswanath,Hsieh, Lily C.,Brown, Kimberly K.,Easwaran, Vijayasurian,Janusz, Michael J.
, p. 3646 - 3650 (2007/10/03)
A new class of lymphocyte specific tyrosine kinase (lck) inhibitors based on an N-4,6-pyrimidine-N-alkyl-N′-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar inhibition of lck kinase activity as well as IL-2 synthesis from Ju
