903594-07-0Relevant articles and documents
HIV integrase inhibitors with nucleobase scaffolds: Discovery of a highly potent anti-HIV agent
Nair, Vasu,Chi, Guochen,Ptak, Roger,Neamati, Nouri
, p. 445 - 447 (2006)
HIV integrase is essential for HIV replication. However, there are currently no integrase inhibitors in clinical use for AIDS. We have discovered a conceptually new β-diketo acid that is a powerful inhibitor of both the 3′-processing and strand transfer s
Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
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Page/Page column 13, (2008/06/13)
A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatmen