6214-65-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Acetyluracil is used as an intermediate in the synthesis of antiviral and anticancer drugs for its potential antiviral properties and its role in creating novel pharmaceuticals.
Used in Antiviral Applications:
5-Acetyluracil is used as an antiviral agent for its ability to inhibit the replication of certain viruses, making it a valuable component in the development of antiviral medications.
Used in Anticancer Drug Development:
5-Acetyluracil is used as a building block in the synthesis of various anticancer drugs, contributing to the creation of innovative and effective cancer treatments.

InChI:InChI=1/C6H6N2O3/c1-3(9)4-2-7-6(11)8-5(4)10/h2H,1H3,(H2,7,8,10,11)

Upstream product

• 6319-01-3 ethyl 2-acetyl-3-ureido-2-propenoate 
• 16029-98-4 trimethylsilyl iodide 
• 83355-88-8 (2,4-dimethoxy-5-pyrimidinyl) acetylene 
• 6214-64-8 ethyl 2-hydroxy-4-methylpyrimidine-5-carboxylate 
• 61751-45-9 5-(α-Chlorovinyl)-2,4-dichloropyrimidine 

Downstream Products

• 121924-16-1 butoxycarbonyl-4 methyl-3 phenyl-1 pyrazole 
• 121902-77-0 phenylhydrazone de l'acetyl-5 uracile 
• 121902-78-1 methyl-3 phenyl-1 oxo-6 dihydro-6,7 pyrazolo<3,4-d>pirimidine 
• 121902-76-9 allophanoyl-4 methyl-3 phenyl-1 pyrazole 
• 78703-53-4 1,3-dimethyl-1H-pyrazole-4-carboxylic acid 
• 36980-95-7 5-(1,3-Dimethyl-2,4-dioxopyrimidil)methyl ketone 
• 40704-11-8 3-methyl-1H-pyrazole-4-carboxylic acid 
• 121902-74-7 allophanoyl-4 methyl-3 pyrazole 
• 59090-41-4 5-acetyl-1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil 
• 903594-07-0 1,3-bis(2-fluorobenzyl)-5-acetyluracil 
• 875296-11-0 5-acetyl-1,3-dibenzyluracil 
• 903594-08-1 1,3-bis(4-fluorobenzyl)-5-acetyluracil 
• 875296-12-1 4-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2,4-dioxo-butyric acid methyl ester 
• 77169-11-0 3-Methyl-1-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Investigation on possibility of rearrangement of pyrimidine-5-carboxylic acids esters

A previously reported rearrangement of pyrimidine-5-carboxylic acids esters to 5-acylpyrimidones does not, in fact, occur in any of the examples studied by us.

HIV integrase inhibitors with nucleobase scaffolds: Discovery of a highly potent anti-HIV agent

HIV integrase is essential for HIV replication. However, there are currently no integrase inhibitors in clinical use for AIDS. We have discovered a conceptually new β-diketo acid that is a powerful inhibitor of both the 3′-processing and strand transfer s

Isomerization/recyclization of some 5-ethoxycarbonyl-pyrimidines

This communication reports on the investigation of a new recyclization conversion of a pyrimidine ring, which can be referred to as C-C recyclization. In this reaction the nucleophile cleaves the pyrimidine ring at the N(3)-C(4) bond, and following rotation around the single C(5)-C(6) bond the new cyclization takes place. This type of recyclization has general applicability, and takes place upon alkali treatment of substituted 4-methyl-5-ethoxycarbonyl- and 4-amino-5-ethoxycarbonyl-pyrimidines (1) which are transformed respectively to 4-hydroxy-5-acetyl- and 4-hydroxy-5-carbamoylpyrimidines (2). The obtained pyrimidyl-ketones can be readily converted to their hydrazones 7-12.

CYCLIZATION DICHOTOMY OF ESTERS OF 3-UREIDO-2-CYANO-2-PROPENOIC AND 3-UREIDO-2-ACYL-2-PROPENOIC ACIDS

The preparation of E and Z isomers of 3-ureido-2-cyano-2-propenoates Ia-Id and their base-catalyzed isomerization and cyclization to 5-carboxycytosine derivatives IIa-IIf and 5-cyanouracil derivatives IIIa and IIIb is described.Also described is the preparation of 3-ureido-2-acyl-2-propenoates Va-Vd and their base-catalyzed cyclization to 5-carboxy-2(1H)-pyrimidone derivatives VIa-VIc and 5-acyluracils VIIa-VIIc.