903898-37-3Relevant academic research and scientific papers
Development of a scalable synthesis of a nonbasic inhibitor of the serine protease tryptase
Dener, Jeffrey M.,O'Bryan, Colin,Yee, Robert,Shelton, Emma J.,Sperandio, David,Mahajan, Tania,Palmer, James T.,Spencer, Jeffrey R.,Tong, Zhiwei
, p. 4591 - 4595 (2006)
A chromatography-free process for the synthesis of a bis(benzimidazole)difluoromethane inhibitor of the serine protease tryptase is described. This synthesis features the introduction of the gem-difluoro moiety using the electrophilic fluorinating reagent N-fluoro-bis(phenylsulfonimide) as well as the stepwise introduction of both benzimidazole rings. A protocol for the destruction of reactive, process-related substances produced in the synthesis is also presented.
