Tetrahedron Letters p. 4591 - 4595 (2006)
Update date:2022-08-02
Topics:
Dener, Jeffrey M.
O'Bryan, Colin
Yee, Robert
Shelton, Emma J.
Sperandio, David
Mahajan, Tania
Palmer, James T.
Spencer, Jeffrey R.
Tong, Zhiwei
A chromatography-free process for the synthesis of a bis(benzimidazole)difluoromethane inhibitor of the serine protease tryptase is described. This synthesis features the introduction of the gem-difluoro moiety using the electrophilic fluorinating reagent N-fluoro-bis(phenylsulfonimide) as well as the stepwise introduction of both benzimidazole rings. A protocol for the destruction of reactive, process-related substances produced in the synthesis is also presented.
View MorePINGYUAN SIHUAN PHARMACEUTICAL CO., LTD
Contact:+86-531-55696072
Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
Contact:+44 (0)2036089360-31
Address:Chanceryhouse,Chancery Lan
website:http://www.eastarchem.com/
Contact:1-800-898-2436
Address:1215 K Street, STE 1700
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Zibo Linzi Darong Fine Chemical Co., Ltd(expird)
Contact:86-532-67773200; 15689126900
Address:Qidu town,Linzi district,Zibo city,Shandong province,China
Doi:10.1002/ardp.19843170402
(1984)Doi:10.1016/S0040-4039(86)80061-2
(1986)Doi:10.1016/j.carres.2006.03.017
(2006)Doi:10.1016/S0040-4039(00)99947-7
(1984)Doi:10.1002/jlcr.934
(2005)Doi:10.1021/jo060598e
(2006)