90399-67-0

Usage

General Description

1-Propanone, 2-bromo-3-methoxy-3-(4-methoxyphenyl)-1-phenyl- is a chemical compound with the molecular formula C14H15BrO3. Also known as 2-Bromo-3-methoxy-3-(4-methoxyphenyl)-1-phenyl-1-propanone, 1-Propanone, 2-bromo-3-methoxy-3-(4-methoxyphenyl)-1-phenyl- is a derivative of 2-Bromo-1-phenylpropan-1-one with additional methoxy and phenyl groups. It is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical has a number of potential applications in the field of medicinal chemistry and drug development due to its unique structure and properties.

Upstream product

• 67-56-1 methanol 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 50793-44-7 2-bromo-3-(4-methoxyphenyl)-1-phenyl-2-propen-1-one 

Relevant academic research and scientific papers

Organocatalysis in the stereoselective bromohydrin reaction of alkenes

An efficient regio- and stereo-selective (>99:1) trans-bromohydrination (bromohydroxylation and bromomethoxylation) of alkenes including α,β-unsaturated carbonyl compounds with N-bromosuccinimide (NBS) has been achieved by using 1.0 mol% of N,N'-diarylthi

Comparative study of the vicinal functionalization of olefins with 2:1 bromide/bromate and iodide/iodate reagents

A comparative evaluation was made on the syntheses of vicinal halohydrins, halo methyl ethers, and halo acetates from olefins using 2:1 Br-/BrO3- and I-/IO3- reagents. In many cases both reagents afforded products selectively in high yields. The highest halogen atom efficiencies attained were 97% and 93% for Br-/BrO3- and I-/IO3-, respectively. Of the two reagents, I-/IO3- was established to be the preferred reagent for vicinal functionalization of linear alkenes and also for halo acetate preparation. However, only Br-/BrO3- was effective for vicinal functionalization of trans-stilbene and chalcones.

Action of tetrabutylammonium tribromide with para-substituted chalcones in protic and aprotic media

Bromination of the double bond of para-substituted chalcones under mild conditions in aprotic solvents is accomplished with high yields using tetrabutylammonium tribromide (TBABr3).In methanol, the main reaction is (α-β) bromoethoxylation.Stereoselectivity, regioselectivity, and chemioselectivity of this bromomethoxylation reaction are described.Key words: bromination, bromoethoxylation, tetrabutylammonium tribromide, (α-β) dibromodihydrochalcones, α-bromo-β-methoxydihydrochalcones.