90430-71-0Relevant academic research and scientific papers
Desulfurizing agent for thioamides
Polushina,Zavarzin,Krayushkin,Rodionova,Yarovenko
, p. 383 - 385 (2021/03/03)
Thioamides treated with thionyl chloride in an ionic liquid were successfully converted into amides.
Functionalization of primary ch bonds in picolines toward pyridylthioamides
Ho, Tuan H.,Le, Ha H. K.,Nguyen, Tung T.,Phan, Nam T. S.,To, Tuong A.
, p. 783 - 789 (2020/08/28)
We report a method for coupling of nitroarenes, 2- or 4-methylazaarenes, and elemental sulfur to afford (2-pyridyl)aryl thioamides. Good tolerance of functionalities was observed, including primary and secondary amines, bromo, iodo, ester, and boronic est
Dithiocarboxylic Acids, Dithiocarboxylic Esters, or Thiocarboxylic Amides by Reaction of Methylene-active Chloromethyl Compounds with Sulfur
Thiel, W.,Mayer, R.
, p. 243 - 262 (2007/10/02)
With a mixture of sulfur and amine in DMF at room temperature halomethyl compounds (1,5-10) can be oxidized to give thiocarboxylic acids (2,11-16) and their derivatives (3,4,17-35).We studied this reaction in detail especially with chloroacetic derivatives (11-15) or chloromethyl heterocycles (16) formally derived from chloroacetic acid.The resulting thiooxalic acid derivatives (11-27) represent activated acids and very useful C2-synthons, especially for the synthesis of heterocycles.Oxidation in the presence of triethylamine leads to dithiocarboxylates (11-16) which can be alkylated to dithioesters (17-27) in high yields.As a rule, with different primary and secondary amines instead of tertiary amines these dithiocarboxylates or dithiocarboxylic esters can be transformed already at low temperatures to thioamides (28-35).
