904688-59-1

Basic information

• Product Name: 6-(phenyl)-2-naphthoic acid methyl ester
• Synonyms: 6-(phenyl)-2-naphthoic acid methyl ester
• CAS NO: 904688-59-1
• Molecular Weight: 262.308
• Mol File: 904688-59-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 6-(phenyl)-2-naphthoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(phenyl)-2-naphthoic acid methyl ester(904688-59-1)
• EPA Substance Registry System: 6-(phenyl)-2-naphthoic acid methyl ester(904688-59-1)

Safety Data

• Hazardous Substances Data: 904688-59-1(Hazardous Substances Data)

Upstream product

• 1201594-29-7 methyl 6-(dimethylsulfamayl)oxy-2-naphthoate 
• 98-80-6 phenylboronic acid 
• 1201593-94-3 C₁₇H₁₉NO₄ 
• 591-50-4 iodobenzene 
• 33626-98-1 methyl 6-bromo-2-naphthoate 
• 17763-67-6 Phenyl triflate 
• 108-86-1 bromobenzene 
• 1279101-97-1 C₁₆H₁₉O₆P 
• 1072840-81-3 methyl 6-(pivaloyloxy)-2-naphthoate 
• 591-51-5 phenyllithium 
• 5043-02-7 6-methoxy-2-naphthoic acid methyl ester 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 3262-89-3 triphenylboroxine 
• 117140-86-0 C₁₄H₁₂O₄ 

Downstream Products

• 1421511-85-4 6-phenylnaphthalene-2-carbohydrazide 
• 1421511-93-4 N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-6-phenyl-2-naphthohydrazide 
• 855207-53-3 6-phenyl-2-naphthoic acid 

Relevant articles and documents

Bathocuproine-Enabled Nickel-Catalyzed Selective Ullmann Cross-Coupling of Two sp 2-Hybridized Organohalides

Cross-coupling reactions are essential for the synthesis of complex organic molecules. Here, we report a nickel-catalyzed Ullmann cross-coupling of two sp 2-hybridized organohalides, featuring high cross-selectivity when the two coupling partners are used in a 1:1 ratio. The high chemoselectivity is governed by the bathocuproine ligand. Moreover, the mild reductive reaction conditions allow that a wide range of functional groups are compatible in this Ullmann cross-coupling.

Pd-Catalyzed Suzuki-Miyaura and Hiyama-Denmark Couplings of Aryl Sulfamates

Using a recently discovered precatalyst, the first Pd-catalyzed Suzuki-Miyaura reactions using aryl sulfamates that occur at room temperature are reported. In complementary work, it is demonstrated that a related precatalyst can facilitate the coupling of aryl silanolates, which are less toxic and reactive nucleophiles than boronic acids with aryl chlorides. By combining our results using modern electrophiles and nucleophiles, the first Hiyama-Denmark reactions using aryl sulfamates are reported.

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate

SIRT1 is an NAD+-dependent deacetylase, whose activators have potential therapeutic applications in age-related diseases. Here we report a new class of SIRT1 activators. The activation is dependent on the fluorophore labeled to the substrate. To elucidate the activation mechanism, we solved the crystal structure of SIRT3/ac-RHKKac-AMC complex. The structure revealed that the fluorophore blocked the H-bond formation and created a cavity between the substrate and the Rossmann fold. We built the SIRT1/ac-RHKK ac-AMC complex model based on the crystal structure. Km and Kd determinations demonstrated that the fluorophore decreased the peptide binding affinity. The binding modes of SIRT1 activators indicated that a portion of the activators interacts with the fluorophore through π-stacking, while the other portion inserts into the cavity or interacts with the Rossmann fold, thus increasing the substrate affinity. Our study provides new insights into the mechanism of SIRT1 activation and may aid the design of novel SIRT1 activators.