5043-02-7

Basic information

• Product Name: Methyl 6-Methoxy-2-naphthoate
• Synonyms: Methyl 6-Methoxy-2-naphthoate;methyl 6-methoxynaphthalene-2-carboxylate;6-Methoxy-naphthalene-2-carboxylic acid methyl ester
• CAS NO: 5043-02-7
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.23258
• EINECS: -0
• Mol File: 5043-02-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 128-129 °C
• Boiling Point: 344.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Methyl 6-Methoxy-2-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-Methoxy-2-naphthoate(5043-02-7)
• EPA Substance Registry System: Methyl 6-Methoxy-2-naphthoate(5043-02-7)

Safety Data

• Hazardous Substances Data: 5043-02-7(Hazardous Substances Data)

Usage

General Description

Methyl 6-Methoxy-2-naphthoate is a chemical compound with the molecular formula C13H12O3. It is a derivative of naphthalene, a bicyclic aromatic hydrocarbon. Methyl 6-Methoxy-2-naphthoate is commonly used as an intermediate in the synthesis of organic chemicals and pharmaceuticals. It is also used in the production of dyes, pigments, and as a fragrance ingredient in perfumes and cosmetic products. Methyl 6-Methoxy-2-naphthoate is a pale yellow solid at room temperature and is soluble in organic solvents. It is important to handle this compound with caution due to its potential irritant and harmful effects if ingested or inhaled.

Upstream product

• 123207-13-6 3,3-Dimethoxy-2-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-butyric acid methyl ester 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 58601-32-4 6-methoxy-2-naphthoyl chloride 
• 16712-64-4 6-Hydroxy-2-naphthoic acid 
• 74-88-4 methyl iodide 
• 17295-11-3 methyl 6-hydroxynaphthalene-2-carboxylate 
• 50-00-0 formaldehyd 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 2471-70-7 2-methoxy-6-naphthoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 77-78-1 dimethyl sulfate 
• 5031-78-7 4-phenoxyacetophenone 
• 2215-77-2 4-Phenoxybenzoic acid 

Downstream Products

• 60201-22-1 (6-methoxy-2-naphthyl)methanol 
• 2471-70-7 2-methoxy-6-naphthoic acid 
• 1421511-91-2 N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-6-methoxy-2-naphthohydrazide 
• 26386-94-7 2-methyl-6-methoxynaphthalene 
• 91-57-6 2-Methylnaphthalene 
• 1592-38-7 2-Naphthalenemethanol 
• 904688-59-1 6-(phenyl)-2-naphthoic acid methyl ester 
• 41790-33-4 2-(chloromethyl)-6-methoxynaphthalene 

Relevant articles and documents

Nickel-Catalyzed Alkoxy–Alkyl Interconversion with Alkylborane Reagents through C?O Bond Activation of Aryl and Enol Ethers

A nickel-catalyzed alkylation of polycyclic aromatic methyl ethers as well as methyl enol ethers with B-alkyl 9-BBN and trialkylborane reagents that involves the cleavage of stable C(sp2)?OMe bonds is described. The transformation has a wide substrate scope and good chemoselectivity profile while proceeding under mild reaction conditions; it provides a versatile way to form C(sp2)?C(sp3) bonds that does not suffer from β-hydride elimination. Furthermore, a selective and sequential alkylation process by cleavage of inert C?O bonds is presented to demonstrate the advantage of this method.

Iron-catalyzed oxidative coupling of alkylamides with arenes through oxidation of alkylamides followed by Friedel-Crafts alkylation

FeCl3 in combination with t-BuOOt-Bu as an oxidant was found to be an efficient catalyst for oxidation of alkylamides to α-(tert-butoxy) alkylamides. FeCl2 and CuCl showed, respectively, almost the same and slightly lower activities

SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region)

Certain derivatives and analogues of capsazepine are potent in vitro inhibitors of bronchoconstriction in human small airways. During an investigation of the dependency of the potency on the structural features of the capsazepinoids in the thiourea moiety (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region), it was revealed that capsazepinoids with a thiourea or an amide link between the B-ring and the C-region in general have a good bronchorelaxing activity, while urea is a less attractive choice. Further, it was shown that 1,2,3,4-tetrahydroisoquinolines with a 2-(phenyl)ethyl derivative as the C-region are considerably more potent than those with an octyl group, while 2,3,4,5-tetrahydro-1H-2-benzazepines were found to be more insensitive to the nature of the C-region.