5043-02-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 6-Methoxy-2-naphthoate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various medicinal compounds.
Used in Dye and Pigment Production:
Methyl 6-Methoxy-2-naphthoate is used as a component in the production of dyes and pigments, owing to its chemical properties that lend themselves to color creation and stability.
Used in Fragrance Industry:
Methyl 6-Methoxy-2-naphthoate is used as a fragrance ingredient in perfumes and cosmetic products, capitalizing on its aromatic qualities to enhance the scent profiles of these products.
Safety Note:
It is important to handle Methyl 6-Methoxy-2-naphthoate with caution due to its potential irritant and harmful effects if ingested or inhaled, emphasizing the need for proper safety measures during its use and manipulation.

Upstream product

• 67-56-1 methanol 
• 58601-32-4 6-methoxy-2-naphthoyl chloride 
• 17295-11-3 methyl 6-hydroxynaphthalene-2-carboxylate 
• 74-88-4 methyl iodide 
• 16712-64-4 6-Hydroxy-2-naphthoic acid 
• 2471-70-7 2-methoxy-6-naphthoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 77-78-1 dimethyl sulfate 
• 5031-78-7 4-phenoxyacetophenone 
• 201230-82-2 carbon monoxide 
• 123207-13-6 3,3-Dimethoxy-2-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-butyric acid methyl ester 
• 2215-77-2 4-Phenoxybenzoic acid 
• 50-00-0 formaldehyd 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 

Downstream Products

• 60201-22-1 (6-methoxy-2-naphthyl)methanol 
• 2471-70-7 2-methoxy-6-naphthoic acid 
• 26386-94-7 2-methyl-6-methoxynaphthalene 
• 91-57-6 2-Methylnaphthalene 
• 1592-38-7 2-Naphthalenemethanol 
• 1421511-91-2 N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-6-methoxy-2-naphthohydrazide 
• 904688-59-1 6-(phenyl)-2-naphthoic acid methyl ester 
• 41790-33-4 2-(chloromethyl)-6-methoxynaphthalene 

Relevant academic research and scientific papers

Nickel-Catalyzed Alkoxy–Alkyl Interconversion with Alkylborane Reagents through C?O Bond Activation of Aryl and Enol Ethers

A nickel-catalyzed alkylation of polycyclic aromatic methyl ethers as well as methyl enol ethers with B-alkyl 9-BBN and trialkylborane reagents that involves the cleavage of stable C(sp2)?OMe bonds is described. The transformation has a wide substrate scope and good chemoselectivity profile while proceeding under mild reaction conditions; it provides a versatile way to form C(sp2)?C(sp3) bonds that does not suffer from β-hydride elimination. Furthermore, a selective and sequential alkylation process by cleavage of inert C?O bonds is presented to demonstrate the advantage of this method.

Palladium-catalyzed carbonylations of aryl bromides using paraformaldehyde: Synthesis of aldehydes and esters

Carbonylation reactions represent useful tools for organic synthesis. However, the necessity to use gaseous carbon monoxide is a disadvantage for most organic chemists. To solve this problem, novel protocols have been developed for conducting palladium-catalyzed reductive carbonylations of aryl bromides and alkoxycarbonylations using paraformaldehyde as an external CO source (CO gas free). Hence, aromatic aldehydes and esters were synthesized in moderate to good yields.

Iron-catalyzed oxidative coupling of alkylamides with arenes through oxidation of alkylamides followed by Friedel-Crafts alkylation

FeCl3 in combination with t-BuOOt-Bu as an oxidant was found to be an efficient catalyst for oxidation of alkylamides to α-(tert-butoxy) alkylamides. FeCl2 and CuCl showed, respectively, almost the same and slightly lower activities

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS

The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can a

NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

Nickel-catalyzed cross-coupling of aryl methyl ethers with aryl boronic esters

(Chemical Equation Presented) To C-OMe and go: The title reaction, involving cleavage of a C-OMe bond, is demonstrated for the coupling of aryl methyl ethers on fused aromatic systems, such as naphthalene and phenanthrene, as well as anisoles containing electron-withdrawing groups with a wide range of boronic esters. cod=cycloocta-1,5-diene, Cy=cyclohexyl.

SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region)

Certain derivatives and analogues of capsazepine are potent in vitro inhibitors of bronchoconstriction in human small airways. During an investigation of the dependency of the potency on the structural features of the capsazepinoids in the thiourea moiety (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region), it was revealed that capsazepinoids with a thiourea or an amide link between the B-ring and the C-region in general have a good bronchorelaxing activity, while urea is a less attractive choice. Further, it was shown that 1,2,3,4-tetrahydroisoquinolines with a 2-(phenyl)ethyl derivative as the C-region are considerably more potent than those with an octyl group, while 2,3,4,5-tetrahydro-1H-2-benzazepines were found to be more insensitive to the nature of the C-region.

MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF

Compounds with α7 nicotinic acetylcholine receptor (α7 nAChR) agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological and psychiatric diseases.

Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia

This invention provides compounds of Formula I having the structure wherein: R1 is hydroxyl, alkoxy of 1-4 carbons or —O(CH2)nX; n is an integer of 1-3; X is CONHR6 or CO2R6; R2

NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)

Where Y, R1-R8 and R101-R108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy.