90481-83-7

Usage

Sulfonyl derivative

1H-Indole, 4-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]is derived from the 1H-Indole structure with a sulfonyl group (-SO2) attached to it.

Presence of halogen atoms

The compound contains both bromine and iodine atoms, which may contribute to its unique properties and reactivity.

Potential applications

1H-Indole, 4-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]- has potential applications in medicinal chemistry and pharmaceutical research due to its unique structure and potential biological activities.

Handling and storage

1H-Indole, 4-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]requires careful handling and storage due to its potential reactivity and toxicity.

Usage restrictions

It should only be used by trained professionals in a controlled laboratory setting to minimize risks associated with its potential reactivity and toxicity.

Need for further research

More research is needed to fully understand the properties and potential uses of this chemical, as its behavior and interactions with other compounds are not yet well-established.

Upstream product

• 90481-79-1 4-bromo-3-(chloromercurio)-1-tosylindole 
• 52488-36-5 4-bromo-1H-indole 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 108868-37-7 4-bromo-3-(2-acetamido-2-carbomethoxyethen-1-yl)-1-tosylindole 
• 108948-30-7 2,3-dicarbomethoxy-1,5-ditosyl-5,6-dihydro-6-(2-methyl-1-propenyl)azepino<5,4,3-cd>indole 
• 108948-29-4 1,5-ditosyl-5,6-dihydro-6-(2-methyl-1-propenyl)azepino<5,4,3-cd>indole 
• 108948-33-0 1-tosyl-5,6-dihydro-5-carbobenzoxy-6-(2-methyl-1-propenyl)azepino<5,4,3-cd>indole 
• 108948-28-3 1-tosyl-5,6-dihydro-5-carbomethoxy-6-(2-methyl-1-propenyl)azepino<5,4,3-cd>indole 
• 108948-27-2 3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole 
• 108948-26-1 4-(3-methyl-1,3-butadien-1-yl)-3-<2-(methoxyimino)ethyl>-1-tosylindole 
• 108948-24-9 4-bromo-3-(2,2-diethoxyethyl)-1-tosylindole 
• 108948-25-0 4-bromo-3-<2-(methoxyimino)ethyl>-1-tosylindole 
• 108894-42-4 3-(2-acetamido-2-carbomethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole 
• 108868-38-8 (Z)-2-Acetylamino-3-[4-((E)-3-hydroxy-3-methyl-but-1-enyl)-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid methyl ester 
• 108894-43-5 2-Acetylamino-3-[4-((E)-3-methyl-buta-1,3-dienyl)-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propionic acid methyl ester 
• 108868-39-9 5-Acetyl-6-(2-methyl-propenyl)-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-azepino[5,4,3-cd]indole-4-carboxylic acid methyl ester 
• 108868-40-2 3-(2-acetamido-2-carbomethoxyethyl)-4-bromo-1-tosylindole 

Relevant academic research and scientific papers

Enantioselective Synthesis of Cyclohepta[ b]indoles via Pd-Catalyzed Cyclopropane C(sp3)-H Activation as a Key Step

An enantioselective synthesis of functionalized cyclohepta[b]indoles via Pd-catalyzed cyclopropane C-H activation followed by olefination and indole-vinylcyclopropane rearrangement is reported. The design of the chiral cyclopropane precursor was such that both enantiomeric cyclohepta[b]indoles were accessed from a single compound exhibiting a "hidden" symmetry plane. The scope of the method was demonstrated by varying the substituents on the cyclopropane as well as on the heterocycle itself.

H-bonding vs Protonation of Alkynes in Regioselective Hydroamination Reactions: A Glimpse into the Reactivity of Arylogous Ynolethers and Ynamines

In this paper is described the competition and transition between hydrogen bonding and protonation of alkynes connected, on one side, to various aromatic rings and to chiral amino ester appendages on the other side. While the first mode of activation indu

Palladium-Catalyzed Reactions in the Synthesis of 3- and 4-Substituted Indoles. Approaches to Ergot Alkaloids

An efficient synthesis of 4-bromo-1-tosylindole (10) based on the Pd(II)-catalyzed cyclization of an o-ethenylaniline p-toluenesulfonamide has been developed.A Pd(0) oxidative addition-olefin insertion-β-hydride elimination cycle converted 10 to a number of 4-substituted 1-tosylindoles.Selective electrophilic substitutions at the 3-position of 10 provided access to the 3-(chloromercurio)- (18) and 3-iodo-1-tosylindoles (22).Transmetalation to palladium and allyl chloride insertion converted 18 to 3-allyl-4-bromo-1-tosylindole (20) which could be cyclized to the benzindoline 21.A Pd(0) oxidative addition-olefin insertion-β-hydride elimination cycle converted the 3-iodo compound 22 to a number of 4-bromo-3-substituted 1-tosylindoles including 24, a potential precursor to optically active tryptophans.