90490-41-8

Upstream product

• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 773-47-7 dimethyl benzylphosphonate 

Downstream Products

• 90490-42-9 methyl benzylphosphonic hydrazide 
• 90490-44-1 methyl benzylphosphonic azide 
• 92074-45-8 methyl N-phenylbenzylphosphonamidate 
• 869881-82-3 2-(benzyl-methoxy-phosphinoyloxy)-benzoic acid methyl ester 
• 869881-83-4 2-methoxy-2-oxo-3-phenyl-2,3-dihydro-2λ⁵-benzo[e][1,2]oxaphosphinin-4-one 
• 869881-95-8 toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ⁵-benzo[e][1,2]oxaphosphinin-4-yl ester 
• 90490-45-2 methyl benzylphosphonic triphenylphosphinimine 
• 92074-46-9 methyl N-methyl-N-phenylbenzylphosphonamidate 
• 92074-47-0 methyl N-methyl-N-(p-bromophenyl)benzylphosphonamidate 

Relevant academic research and scientific papers

Synthesis of a diverse series of phosphacoumarins with biological activity

(Chemical Equation Presented) We have developed a general and efficient approach to a diverse series of phosphacoumarins as analogues of coumarins with various biological activities, and the inhibitory activity of the synthesized phosphacoumarins against the enzyme SHP-1, a protein tyrosine phosphatases, was tested. Some of them showed moderate to good efficiency.

Organphosphorus Compounds. XVIII. Synthesisi of 2-Phenyl-2,3-dihydro-1H-1,2-benzazaphosphole 2-Sulfide by Pyrolysis of (2-Aminobenzyl)phenyldithiophosphonic Acid

Reaction of 2-phthalimidobenzyl bromide (12b) with the dialkyl phenylphosphonites (13a-c) afforded the corresponding alkyl phosphinates (14a-c) which upon hydrazinolysis yielded the respective (2-aminobenzyl)phenylphosphinates (16a-c).Reduction of the phosphinates (16a) or (16b) with lithium aluminium hydride gave (2-aminobenzyl)phenylphosphine (15), characterized by its conversion into crystalline 2,3-diphenyl-1,2,3,4-tetrahydro-1,3-benzazaphosphorine (18). (2-Aminobenzyl)phenylphosphine (15) was heated with sulfur in benzene under reflux for 30 min to give 80percent of (2-aminobenzyl)phenyldithiophosphinic acid (20) which when heated between 100-200 deg in vacuum underwent elimination of hydrogen sulfide to yield 2-phenyl-2,3-dihydro-1H-1,2-benzazaphosphole 2-sulfide (22a).Several other new phosphorus compounds are described.An attempt to prepare a 1H-1,2-benzazaphosphole derivative by photolysis of methyl benzylphosphonic azide (7) was unsuccessful.