90490-79-2Relevant academic research and scientific papers
Oxidative ortho-amino-methylation of phenols via C-H and C-C bond cleavage
Sun, Wenbo,Lin, Huacan,Zhou, Wenyu,Li, Zigang
, p. 7491 - 7494 (2014/02/14)
Initiated by CCl3Br, phenols undergo efficient ortho-selective oxidative cross dehydrogenative coupling (CDC) with trimethylamine. When tetramethylethylenediamine (TMEDA) is used instead of trimethylamine, oxidative carbon-carbon activation coupling (CAC) could occur to give the same salicylamines together with CDC by-products. These reactions are accelerated by a gold salt.
Synthesis of substituted salicylamines and dihydro-2H-1,3-benzoxazines
Anwar, Hany F.,Skatteb?l, Lars,Hansen, Trond Vidar
, p. 9997 - 10002 (2008/02/13)
Phenols were converted to their magnesium salts with the MgCl2-Et3N base system and subsequently reacted with Eschenmoser's salt, affording N,N-dimethyl substituted benzylamines in high to excellent yields. A series of mono N-substituted benzylamines were prepared in one-pot syntheses by ortho-formylation of phenols to corresponding salicylaldehydes, which in turn reacted with amines to imines. The imines were subsequently reduced to mono N-substituted benzylamines. Some of these benzylamines were further converted, without work-up, to mono N-substituted dihydro-2H-1,3-benzoxazines.
