90503-15-4

Usage

Uses

Used in Pharmaceutical Industry:
1-AMINO-3-BENZYLOXY-PROPAN-2-OL is used as an aldose reductase inhibitor for treating diseases caused by insulin resistance. Aldose reductase is an enzyme involved in the polyol pathway, which is implicated in the development of complications associated with diabetes, such as diabetic retinopathy, nephropathy, and neuropathy. By inhibiting aldose reductase, 1-AMINO-3-BENZYLOXY-PROPAN-2-OL can help manage and prevent these complications in patients with insulin resistance or diabetes.

InChI:InChI=1/C10H15NO2/c11-6-10(12)8-13-7-9-4-2-1-3-5-9/h1-5,10,12H,6-8,11H2

Upstream product

• 2930-05-4 Benzyloxymethyl-oxiran 
• 99805-19-3 (R,S)-1-azido-3-benzyloxy-2-propanol 
• 100-51-6 benzyl alcohol 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 90503-16-5 2-(3-(benzyloxy)-2-hydroxypropyl)isoindoline-1,3-dione 

Downstream Products

• 141870-42-0 cis-5-benzyloxymethyl-3-formyl-2-methyl-1,3-oxazolidine 
• 141870-42-0 trans-5-benzyloxymethyl-3-formyl-2-methyl-1,3-oxazolidine 
• 1350881-26-3 2-{ [3-(benzyloxy)-2-hydroxypropyl]amino}-4-phenylbutan-1-ol 
• 90503-17-6 1-benzyloxy-2-chloromethoxy-3-phthaloylimidopropane 
• 158832-16-7 5-benzyloxymethyl-3-(4-bromobutyl)-2-oxazolidinone 
• 113681-81-5 N-(3-Benzyloxy-2-hydroxy-propyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide 
• 90503-16-5 2-(3-(benzyloxy)-2-hydroxypropyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

Phthalimide resin reagent for efficient mitsunobu amino-dehydroxylation

A phthalimide-containing resin has been designed and prepared from trimellitic anhydride. It provides an efficient route to primary amines from corresponding alcohols via Mitsunobu coupling with subsequent hydrazine- induced cleavage.

Thiazolidine and oxazolidine derivatives, their preparation and their medical use

Compounds of formula (I): STR1 and salts, esters and solyates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.

A palladium-catalyzed, abnormal hydrogenolytic ring-cleavage reaction of fused β-lactams

Bicyclic β-lactams, such as 1-oxa- and 1-carba-penams, are reductively cleaved between the lactam carbonyl group and the α-carbon by palladium catalysts to give formamide derivatives.

HYDROPHILIC 1-(CARBOXYMETHYL)-5-FLUOROURACIL AMIDES: PREPARATION AND CYTOSTATIC ACTIVITY

The following N-substituted amides IV were prepared by reaction of 1-(carboxymethyl)-5-fluorouracil p-nitrophenyl ester (II) with primary or secondary hydroxyalkylamines III: 2-hydroxypropyl (IVa), 3-hydroxypropyl (IVb), 2,3-dihydroxypropyl (IVc), 3-hydroxy-2-methyl-2-propyl (IVd), 1,3-dihydroxy-2-propyl (IVe), 1-deoxyglucitol-1-yl (IVg), 2-deoxyglucitol-2-yl (IVh), methyl-2,3-dihydroxypropyl (IVi), methyl-1-deoxyglucitol-1-yl (IVk), and n-butyl-2,3-dihydroxypropyl(IVl).None of these compounds had any cytostatic activity towards murine leukemia L-1210 cell growth in a tissue culture at 10-5 mol l-1.

A novel method for the synthesis of 9-[[2-hydroxy-1-(aminomethyl)ethoxy]methyl]guanine. A potential antiviral agent

9-[[2-Hydroxy-1-(aminomethyl)ethoxy]methyl]guanine (1a), an amino analogue of 9-[[2-hydroxy-1-(hydroxymethyl)-ethoxy]methyl]guanine (I) which is a potent antiviral agent, has been synthesized via a multistep-synthesis.