99805-19-3Relevant academic research and scientific papers
Silica-tethered cuprous acetophenone thiosemicarbazone (STCATSC) as a novel hybrid nano-catalyst for highly efficient synthesis of new 1,2,3-triazolyl-based metronidazole hybrid analogues having potent antigiardial activity
Soltani Rad, Mohammad?Navid,Behrouz, Somayeh,Mohammadtaghi-Nezhad, Javad,Zarenezhad, Elham,Agholi, Mahmoud
, (2019/02/03)
The preparation, characterization and application of silica-tethered cuprous acetophenone thiosemicarbazone (STCATSC) as a novel hybrid nano catalyst for synthesis of new 1,2,3-triazolyl-based metronidazole hybrid analogues is described. STCATSC is fully
Montmorillonite K10 catalyzed highly regioselective azidolysis of epoxides: A short and efficient synthesis of phenylglycine
Ch Ghosh, Keshab,Banerjee, Isita,Sinha, Surajit
supporting information, p. 2923 - 2934 (2018/12/04)
A series of β‐hydroxyazides were effectively synthesized from the regioselective ring opening of epoxides by sodium azide using montmorillonite K10 as a novel heterogeneous catalyst in aqueous acetonitrile in good to excellent yields. The utility of this method has been demonstrated by achieving a short synthesis of phenylglycine in 33.5% overall yield.
HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
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Paragraph 00188, (2017/05/02)
The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY
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Paragraph 0237; 0238, (2017/01/09)
The present invention provides a compound of formula (I), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity,
GLS1 INHIBITORS FOR TREATING DISEASE
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Paragraph 0316, (2016/01/25)
Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I. Methods of inhibition GLS1 activity in a human or animal subject are also provided.
Phosphine-catalyzed heine reaction
Martin, Allen,Casto, Kathleen,Morris, William,Morgan, Jeremy B.
supporting information; experimental part, p. 5444 - 5447 (2011/12/05)
Aziridines are important synthetic intermediates which readily undergo ring-opening reactions. It is demonstrated that electron-rich phosphines are efficient catalysts for the regioselective rearrangement of N-acylaziridines to oxazolines. The reactions o
Library of 1,4-disubstituted 1,2,3-triazole analogs of oxazolidinone RNA-binding agents
Acquaah-Harrison, George,Zhou, Shu,Hines, Jennifer V.,Bergmeier, Stephen C.
scheme or table, p. 491 - 496 (2010/09/15)
The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the RNA binding of a series of 4,5-disubstituted 2-oxazolidinones that bind to a highly conserved bulge region of bacterial RNA. This biological target T box antitermination system, which is found mainly in Gram-positive bacteria, regulates the expression of several amino acid related genes. In an effort to amplify our library, we have prepared a library of 1,4-disubstituted 1,2,3-triazole analogs that entails an isosteric replacement of the oxazolidinone nucleus. The synthesis of the new analogs was enhanced via copper(I) catalysis of an azide and alkyne cycloaddition reaction. A total of 108 1,4-disubstituted 1,2,3-triazole compounds have been prepared. All compounds were evaluated as RNA binding agents.
Intramolecular reductive amination strategy to the synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-2-benzylmorpholine
Sawant, Rajiv T.,Waghmode, Suresh B.
experimental part, p. 2010 - 2014 (2010/04/26)
A concise high yielding enantioselective synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-benzylmorpholine has been achieved by employing proline-catalyzed asymmetric α-aminooxylation of aldehyde and palladium-catalyzed intramolecular reductive amination of azido aldehyde as the key steps.
Gallium trichloride - Promoted highly regioselective ring opening of epoxides with NH4SCN and NaN3 in water
Chen, Xian,Wu, Huayue,Xu, Rong,Liu, Miaochang,Ding, Jinchang,Su, Weike
, p. 1855 - 1865 (2008/09/21)
β-Hydroxy thiocyanates and β-azidoalchols were obtained in excellent yields via GaCl3-promoted highly regioselective ring opening of epoxides with ammonium thiocyanate or sodium azide in water. The present method is very rapid and equally compatible for b
Ionic liquids/H2O systems for the reaction of epoxides with NaN3: A new protocol for the synthesis of 2-azidoalcohols
Yadav,Reddy,Jyothirmai,Murty
, p. 6559 - 6562 (2007/10/03)
Oxiranes undergo ring opening rapidly with sodium azide in a [bmim]BF 4/H2O or [bmim]PF6/H2O (2:1) solvent system, under mild and neutral reaction conditions to afford the corresponding 2-azidoalcohols in high t
