90526-08-2

Usage

Uses

Used in Organic Synthesis:
2-(3-METHOXY-PHENYL)-N,N-DIMETHYL-ACETAMIDE is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, facilitating the synthesis of complex organic molecules. It is particularly useful in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals, where its reactivity and selectivity can be harnessed to produce desired products with high efficiency and yield.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(3-METHOXY-PHENYL)-N,N-DIMETHYL-ACETAMIDE is utilized as a key building block in the development of new drugs. Its ability to form a variety of chemical bonds and its compatibility with other molecular fragments make it an ideal candidate for the creation of novel drug molecules with potential therapeutic applications. Researchers can use 2-(3-METHOXY-PHENYL)-N,N-DIMETHYL-ACETAMIDE to explore new chemical space and design innovative pharmaceutical agents that address unmet medical needs.
Used in Agrochemical Industry:
2-(3-METHOXY-PHENYL)-N,N-DIMETHYL-ACETAMIDE also finds application in the agrochemical industry, where it serves as a precursor for the synthesis of new pesticides, herbicides, and other crop protection agents. Its unique chemical properties enable the development of more effective and environmentally friendly agrochemicals, contributing to sustainable agriculture and food security.

Upstream product

• 124-40-3 dimethyl amine 
• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 1798-09-0 m-methoxyphenylacetic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 99540-20-2 (6-iodo-3-methoxy)phenyl-N,N-dimethylacetamide 
• 69384-63-0 3-(2-(dimethylamino)ethyl)phenol 
• 130198-49-1 1-[2-(dimethylamino)-1-(3-methoxyphenyl)ethyl]cyclohexanol 
• 130198-53-7 1-[2-(dimethylamino)-1-(3-methoxyphenyl)ethyl]cyclopentanol 
• 61134-88-1 2-(3-methoxyphenyl)-N,N-dimethylethan-1-amine 
• 698357-97-0 2-[(2',6'-dichlorophenyl)amino]-5-hydroxyphenyl-N,N-dimethylacetamide 
• 698357-92-5 2-[(2',6'-dichlorophenyl)amino]-5-methoxyphenyl-N,N-dimethylacetamide 
• 69002-84-2 2-(2-((2,6-dichlorophenyl)amino)-5-hydroxyphenyl)acetic acid 

Relevant academic research and scientific papers

Pd-Catalyzed Site-Selective p-Hydroxyphenyloxylation of Benzylic α-C(sp3)-H Bonds with 1,4-Benzoquinone

A Pd-catalyzed, site-selective p-hydroxyphenyloxylation of benzylic α-C(sp3)-H bonds with 1,4-benzoquinone using thioamide as a directing group is reported. 1,4-Benzoquinone is employed as the p-hydroxyphenyloxy source without extra oxidants. T

Copper-catalyzed amidation of acids using formamides as the amine source

Copper-catalyzed amidation of acids with formamides or acetamide for the selective synthesis of amides with the aid of 1,4-diazabicyclo[2.2.2]octane as the ligand and tert-butyl hydroperoxide as the oxidant is presented. This method is highly compatible with a wide range of acids, including alkyl acids, aryl acids, α,β-unsaturated acids, and amino acids. A general and direct route for the synthesis of amides is described. The reaction involves the copper-catalyzed amidation of acids, wherein various formamides and an acetamide are used as the amine source. Importantly, this method represents a new strategy for the direct use of acids in the synthesis of amides. DABCO = 1,4-diazabicyclo[2.2.2]octane, TBHP = tert-butyl hydroperoxide. Copyright

2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: Synthesis and antidepressant activity

A series of 2-phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives was examined for the ability to inhibit both rat brain imipramine receptor binding and the synaptosomal uptake of norepinephrine (NE) and serotonin (5-HT). Neurotransmitter uptake inhibition was highest for a subset of 2-phenyl-2-(1-hydroxycyclohexyl)dimethylethylamines in which the aryl ring has a halogen or methoxy substituent at the 3- and/or 4-positions. Potential antidepressant activity in this subset was assayed in three rodent models - the antagonism of reserpine-induced hypothermia, the antagonism of histamine-induced ACTH release, and the ability to reduce noradrenergic responsiveness in the rat pineal gland. An acute effect seen in the rat pineal gland with several analogues, including 1-[1-(3,4-dichlorophenyl)-2-(dimethylamino)ethyl]cyclohexanol (23) and 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (4), was taken as a possible correlate of a rapid onset of antidepressant activity. Compound 4 (venlafaxine) is presently undergoing clinical evaluation.