224048-12-8

Upstream product

• 26742-33-6 (4aS)-1,4aβ-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione-5-ethyeneacetal 
• 224048-24-2 (2ζ,4aS,8aS)-2,5,5,8a-Tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1(2H)-one 
• 91547-50-1 (4aS,8aS)-5,5,8a-trimethylhexahydro-2H-spiro[naphthalene-1,2'-[1,3]dioxolan]-6(5H)-one 
• 41722-49-0 (S)-1,4a-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione 
• 57440-68-3 2-methyl-2-(3-oxopentyl)-1,3-cyclohexanedione 
• 20404-65-3 (-)-(2R,4aS,8aS)-2,5,5,8a-Tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1(2H)-one 
• 60134-39-6 (-)-(4aS,8aS)-3,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethylnaphthalen-1(2H)-one 
• 91547-54-5 (4aS,8aS)-3,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethylnaphthalen-1(2H)-one ethylene acetal 
• 1193-55-1 2-methylcyclohexane-1,3-dione 

Downstream Products

• 1259067-32-7 C₂₂H₃₁BrO₃ 
• 1259067-33-8 C₂₂H₃₂O₃ 
• 1259067-34-9 C₂₂H₃₂O₃ 
• 905291-19-2 C₂₆H₄₁BrO₄Si 
• 905291-20-5 C₂₃H₃₃BrO₄ 

Relevant academic research and scientific papers

Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal

Analogues of the sponge meroterpenoid liphagal (1) have been synthesized and evaluated for inhibition of PI3Kα and PI3Kα as part of a program aimed at developing new isoform-selective PI3K inhibitors. One of the analogues, compound 24, with IC50/sub

MEROTERPENOID INHIBITORS OF PHOSPHOINOSITIDE 3 KINASE (PI3K)

Compounds with unique liphagane meroterpenoid carbon skeleton are described (structures I, II, III) together with pharmaceutical compositions and their use. A method of inhibiting the activity of phosphoinositide 3 kinase (PBK) is disclosed. In particular

Total synthesis of a monocyclofarnesane norsesquiterpenoid isolated from mushroom ingested by beetle: Utility of solid state Baeyer-Villiger oxidation

Norsesquiterpenoid 1 has been synthesised starting from (S)-(+)-Wieland-Miescher ketone analogue 3 via solid state Baeyer-Villiger oxidation as a key step.