90534-51-3

Basic information

• Product Name: Benzene, 1,3-dimethyl-5-(methylsulfonyl)-
• CAS NO: 90534-51-3
• Molecular Formula: C9H12O2S
• Molecular Weight: 184.259
• Mol File: 90534-51-3.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-dimethyl-5-(methylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dimethyl-5-(methylsulfonyl)-(90534-51-3)
• EPA Substance Registry System: Benzene, 1,3-dimethyl-5-(methylsulfonyl)-(90534-51-3)

Safety Data

• Hazardous Substances Data: 90534-51-3(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 108-38-3 m-xylene 
• 616-42-2 dimethylsulfite 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 512-56-1 trimethyl phosphite 
• 556-96-7 5-bromo-1,3-xylene 
• 67-68-5 dimethyl sulfoxide 
• 2905-27-3 3,5-dimethyl-benzenesulfonyl chloride 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 325142-93-6 2-(3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 134178-05-5 5-(Methylsulfonyl)-1,3-benzenedicarboxylic Acid 
• 686752-98-7 1,5-dimethyl-2-nitro-3-(propane-1-sulfonyl)benzene 
• 349453-78-7 2,4-dimethyl-6-(propane-1-sulfonyl)aniline 
• 349453-70-9 2-methanesulfonyl-4,6-dimethylaniline 
• 923001-88-1 1-diazo-1-(3,5-dimethylphenylsulfonyl)-5-hexen-2-one 
• 923001-96-1 (1R,5R)-1-(3,5-dimethylphenylsulfonyl)bicyclo[3.1.0]hexan-2-one 
• 923002-04-4 1-(3,5-dimethylphenylsulfonyl)-5-hexen-2-one 
• 686752-94-3 ethyl (3,5-dimethylphenyl) sulfone 
• 686752-96-5 3,5-dimethylphenyl-(1-propyl)-sulfone 
• 686752-97-6 1-methanesulfonyl-3,5-dimethyl-2-nitrobenzene 

Relevant articles and documents

Preparation method of methyl sulfone compound

The invention discloses a synthesis method of a methyl sulfone compound, which comprises the following steps: by using an iodinated compound as a substrate, adding a sulfite compound into the substrate, and using a 1, 4-dioxane solution as a solvent, heating under the protection of nitrogen under the actions of a silicon reagent, a phase transfer catalyst and a palladium catalyst to obtain a crudeproduct; then purifying the crude product, firstly filtering the crude product, and removing the solvent to obtain residues; carrying out silica gel column chromatography on the residues, leaching with eluent, and collecting effluent; combining the effluent containing the product; and concentrating the combined effluent to remove the solvent, and finally carrying out vacuum drying to obtain the target product. The method has the advantages of simple process flow, easiness in product purification, environmental safety and high yield.

General sulfone construction: Via sulfur dioxide surrogate control

A highly efficient one-step synthesis of alkyl-alkyl and aryl-alkyl sulfones with a facile combination of halides, sulfur dioxide surrogates and phosphate esters is described. When thiourea dioxide was employed as a reductive sulfur dioxide surrogate, alkyl-alkyl sulfones were obtained under transition metal free conditions. Aryl-alkyl sulfones were obtained with an extremely low catalytic loading (0.2 mol%) via altering the mask of sulfur dioxide surrogates to sodium dithionite. A phosphate ester was employed as a stable and readily available alkyl source. Notably, this protocol has been applied to the late-stage modification of natural products and bioactive molecules.

Copper-catalyzed aerobic oxidation and cleavage/formation of C-S bond: A novel synthesis of aryl methyl sulfones from aryl halides and DMSO

With atmospheric oxygen as the oxidant, a novel copper(i)-catalyzed synthesis of aryl methyl sulfones from aryl halides and widely available DMSO is described. The procedure tolerates aryl halides with various functional groups (such as methoxy, acetyl, chloro, fluoro and nitro groups), which could afford aryl methyl sulfones in moderate to high yields. The copper-catalyzed aerobic oxidation and the cleavage/formation of C-S bond are the key steps for this transformation.

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)

Total Synergistic effect between triflic acid and bismuth(IIIr antimony(III) chlorides in catalysis of the Methanesulfonylation of Arenes

A total synergistic effect between bismuth(III) or antimony(III) chlorides and triflic acid has been observed in the Friedel-Crafts methanesulfonylation of arenes and has resulted in the development of the first efficient catalytic systems usable for the methanesulfonylation of both activated and deactivated arenes. A proposed mechanism to explain the observed effects is also discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl) -thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Sitaxsentan (1) (Wu et al. J. Med. Chem. 1997, 40, 1690) is our first endothelin antagonist being evaluated in clinical trials. It has demonstrated biological effects in an acute hemodynamic study in CHF (Givertz et al. Circulation 2000, 101, 2922), an op

An Efficient Copper Catalyst for the Formation of Sulfones from Sulfinic Acid Salts and Aryl Iodides

(Matrix Presented) A novel copper-catalyzed method for the coupling of sulfinic acid salts and aryl iodides is described. A variety of methyl and diaryl sulfones have been formed in excellent yields.