90539-81-4Relevant academic research and scientific papers
Synthesis and bioactivity assessment of novel spiro pyrazole-oxindole congeners exhibiting potent and selective in vitro anticancer effects
Abdelhamid, Sayeda A.,Abo-Salem, Heba M.,Aboul-Soud, Mourad A. M.,Al-Sheikh, Yazeed A.,Ebied, Manal S.,El-Sawy, Eslam R.,Elawady, Mohamed E.,Nassrallah, Amr,Soliman, Ahmed A. F.
, (2020/03/17)
The present work aims to design and synthesize novel series of spiro pyrazole-3,3'-oxindoles analogues and investigate their bioactivity as antioxidant and antimicrobial agents, as well as antiproliferative potency against selected human cancerous cell li
Formation of indole nucleus via intramolecular cyclization of aminophenylpropenyltriphenylphosphonium salts with one-carbon degradation
Taira, Shin'Ichi,Danjo, Hiroshi,Imamoto, Tsuneo
, p. 8893 - 8896 (2007/10/03)
Treatment of 3-(2-aminophenyl)-2-propenyltriphenylphosphonium bromide with acid anhydride and tertiary amine affords 1,3-diacylindoles in yields ranging from 22 to 64%. A plausible mechanism of this new cyclization reaction is described.
Electrophilic substitution of indoles catalyzed by triphenyl phosphonium perchlorate: Synthesis of 3-acetyl indoles and bis-indolylmethane derivatives
Nagarajan, Rajagopal,Perumal, Paramasivan T.
, p. 105 - 109 (2007/10/03)
Triphenyl phosphonium perchlorate (TPP) is found to catalyze the acetylation of indoles with acetic anhydride to give 3-acetyl indoles. Similarly bis-indolylmethane derivatives were prepared by the electrophilic substitution reaction of indole with substituted benzaldehydes.
Manganese(III) acetate initiated oxidative free radical reaction between benzoylindoles and dimethyl malonate
Wang, Sheow-Fong,Chuang, Che-Ping
, p. 347 - 359 (2007/10/03)
A free radical reaction between benzoylindoles and dimethyl malonate initiated by manganese(III) acetate is described. This free radical reaction provides a new method for the synthesis of indolo[1,2-b]isoquinolines and benzo[b]carbazoles. With meta subst
INDOLE DERIVATIVES. 131.* REACTION OF 1-ACYLINDOLES WITH ACETYLCHLORIDE AND CHLOROACETYLCHLORIDE UNDER FRIEDEL-CRAFTS CONDITIONS
Shner, V.F.,Sladkova, T.N.,Turchin, K.F.,Suvorov, N.N.
, p. 272 - 274 (2007/10/02)
Acylation of 1-acylindoles by acetylchloride and chloroacetylchloride in the presence of aluminium chloride leads to formation of 3-acetyl and 6-chloroacetyl-1-acylindoles, respectively.
Simple N-Alkylation and N-Acylation of 3-Acetylindole and 3-Indolecarbaldehyde
Kurihara, Takushi,Fujimoto, Toshiro,Harusawa, Shinya,Yoneda, Ryuji
, p. 396 - 397 (2007/10/02)
Using lithium cyanide a simple method for the transformation of 3-acetylindole into the N-alkyl, N-acyl, and N-p-toluenesulfonyl derivatives in good yield is reported. 3-Indolecarbaldehyde is also N-alkylated by the same procedure.
Regio- and Stereo-chemical Aspects of Photocycloaddition Between 1-Benzoylindoles and Olefins
Ikeda, Masazumi,Ohno, Kazunori,Mohri, Shin-ichiro,Takahashi, Masami,Tamura, Yasumitsu
, p. 405 - 412 (2007/10/02)
The regio- and stereo-selectivities in the photocycloaddition of a series of 1-benzoylindoles with vinyl acetate and methyl acrylate have been investigated.With some exceptions, the 1-benzoylindoles gave exclusively or predominatly the corresponding 1-acetoxy-3-benzoyl and 3-benzoyl-1-methoxycarbonyl-1,2,2a,7b-tetrahydro-3H-cyclobutindoles as mixtures of stereoisomers.
