905982-89-0Relevant academic research and scientific papers
Synthesis and hetero-Diels-Alder reactions of enantiomerically pure dihydro-1: H -azepines
Craig, Donald,Spreadbury, Samuel R. J.,White, Andrew J. P.
, p. 9803 - 9806 (2020/09/16)
Thermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes in the presence of K2CO3 gives in good yields 2-alkyl-6-halo-1-tosyl-2,3-dihydro-1H-azepines. These undergo highly stereoselective [4+2] cycloaddition reactions with heterodienophiles and arylation/alkenylation under Suzuki conditions.
Development of a [3+3] approach to tetrahydropyridines and its application in indolizidine alkaloid synthesis
Pattenden, Lisa C.,Adams, Harry,Smith, Stephen A.,Harrity, Joseph P.A.
, p. 2951 - 2961 (2008/09/19)
A stepwise [3+3] annelation sequence is described that generates tetrahydropyridines from the corresponding aziridines. The scope of this process is described and its potential for the stereoselective synthesis of indolizidines is highlighted by the synth
A [3+3] annelation approach to tetrahydropyridines
Pattenden, Lisa C.,Wybrow, Robert A. J.,Smith, Stephen A.,Harrity, Joseph P. A.
, p. 3089 - 3091 (2007/10/03)
A stepwise [3+3] annelation sequence to tetrahydropyridines via addition of the Buchi Grignard to aziridines has been developed. These intermediates can be further functionalized with good regio- and stereocontrol and this methodology has been employed in
