90610-06-3Relevant academic research and scientific papers
AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS
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Page/Page column 101, (2010/08/09)
The invention relates to compounds of formula (I), wherein R, R1, m, n and X1to X3 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention
Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists
Ando, Makoto,Sekino, Etsuko,Haga, Yuji,Moriya, Minoru,Ito, Masahiko,Ito, Junko,Iwaasa, Hisashi,Ishihara, Akane,Kanatani, Akio,Ohtake, Norikazu
scheme or table, p. 5186 - 5190 (2010/03/24)
Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy)phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl)phenyl]ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives.
