9063-57-4

Basic information

• Product Name: TUFTSIN
• Synonyms: TUFTSIN;TUFTSIN 2ACOH 4H2O;THR-LYS-PRO-ARG;THR-LYS-PRO-ARG 2ACOH 4H2O;H-Thr-Lys-Pro-Arg-OH;Tuftsin hydrate acetate salt;L-Thr-L-Lys-L-Pro-L-Arg-OH;Taftsin
• CAS NO: 9063-57-4
• Molecular Formula: C₂₁H₄₀N₈O₆
• Molecular Weight: 500.59
• Product Categories: Peptide
• Mol File: 9063-57-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.48g/cm³
• Refractive Index: 1.648
• Storage Temp.: −20°C
• PKA: 3.60±0.21(Predicted)
• CAS DataBase Reference: TUFTSIN(CAS DataBase Reference)
• NIST Chemistry Reference: TUFTSIN(9063-57-4)
• EPA Substance Registry System: TUFTSIN(9063-57-4)

Safety Data

• Hazardous Substances Data: 9063-57-4(Hazardous Substances Data)

Usage

General Description

Tuftsin is a naturally occurring tetrapeptide composed of threonine, arginine, proline, and lysine. It is known to have immunomodulatory properties and is involved in the regulation of the immune response. Tuftsin has been shown to enhance the activity of certain immune cells, such as macrophages and natural killer cells, and to stimulate the production of antibodies. It has also been found to have potential therapeutic applications in the treatment of various diseases, including cancer, autoimmune disorders, and infectious diseases. Additionally, tuftsin has been investigated for its potential to improve the efficacy of vaccines and cancer immunotherapy. Overall, tuftsin is an intriguing molecule with diverse biological activities and potential therapeutic benefits.

InChI:InChI=1/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)

Upstream product

• 78432-02-7 Benzyloxycarbonylthreonyl(ε-tert-butoxycarbonyllysyl)prolylarginine 
• 154509-00-9 Boc-Thr(OBn)-Lys(2Cl,Z)-Pro-Arg(Tos)-OBn 
• 29388-63-4 H-Arg(Tos)-OBzl 
• 13836-37-8 Boc-Arg(Tos)-OH 
• 61543-20-2 Boc-Arg(Tos)-OBzl 
• 66336-82-1 H-Pro-Arg(Tos)-OBn 
• 66336-81-0 Boc-Pro-Arg(Tos)-OBn 
• 154508-97-1 Boc-Lys(2Cl,Z)-Pro-Arg(Tos)-OBn 
• 74-79-3 L-arginine 
• 2212-69-3 N₂-benzyloxycarbonyl-N₆-t-butoxycarbonyl-L-lysine 4-nitrophenyl ester 
• 60889-67-0 N-benzyloxycarbonyl-L-prolyl-L-arginine 
• 55322-38-8 (α-Benzyloxycarbonyl-ε-tert-butoxycarbonyllysyl)prolylarginine 
• 3304-59-4 N-benzyloxycarbonyl-L-proline p-nitrophenyl ester 

Downstream Products

• 72-19-5 L-threonine 
• 56-87-1 L-lysine 
• 74-79-3 L-arginine 
• 147-85-3 L-proline 

Relevant articles and documents

Enantiospecific C-H Activation Using Ruthenium Nanocatalysts

The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.

SYNTHESIS OF THE TETRAPEPTIDE TUFTSIN AND ITS EFFECT ON THE CENTRAL NERVOUS SYSTEM

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