906360-22-3Relevant academic research and scientific papers
Highly flexible synthesis of chiral azacycles via iridium-catalyzed hydrogenation
Verendel, J. Johan,Zhou, Taigang,Li, Jia-Qi,Paptchikhine, Alexander,Lebedev, Oleg,Andersson, Pher G.
, p. 8880 - 8881 (2010/08/22)
A range of saturated chiral azacycles has been prepared in high yield and with high selectivity from simple starting materials. A modular approach with ring-closing metathesis as a key step was used to produce a number of five-, six-, and seven-membered c
Concise synthesis of 3-arylpiperidines
Chang, Meng-Yang,Hsu, Ru-Ting,Chen, Hua-Ping,Lin, Pei-Jung
, p. 1173 - 1183 (2007/10/03)
We present an easy and straightforward synthesis of 3-arylpiperidines by Grignard addition of piperidin-3-one with different arylmagnesium bromide reagents and acidic dehydroxylation of the resulting tertiary alcohol with the combination of triethylsilane and boron trifluoride etherate. This facile strategy was further used to synthesize preclamol. A highly regioselective dehydration of 3-arylpiperidin-3-ol with boron trifluoride etherate was investigated for preparing 3-aryl-1,4,5,6-tetrahydropyridine skeleton. A novel selenium dioxide mediated dihydroperoxidation of 3-aryl-1,4,5,6-tetrahydropyridine was also examined.
