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Upstream product

• 5390-04-5 pent-1-yn-5-ol 
• 98-80-6 phenylboronic acid 
• 1262757-71-0 4-methyl-N-(4-phenylpent-4-en-1-yl)benzenesulfonamide 
• 220384-55-4 1-(p-toluenesulfonyl)-piperidin-3-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 220384-68-9 1-(p-toluenesulfonyl)-piperidin-3-ol 
• 6859-99-0 3-hydroxypiperazine 
• 906360-42-7 3-phenyl-1-(toluene-4-sulfonyl)-piperidin-3-ol 

Relevant academic research and scientific papers

Synthesis of 5-Iodo-1,2,3,4-tetrahydropyridines by Rhodium-Catalyzed Tandem Nucleophilic Attacks Involving 1-Sulfonyl-1,2,3-triazoles and Iodides

Sodium iodide is used for the first time as a nucleophile to trap an α-imino rhodium carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds.

Highly stereoselective metal-free oxyaminations using chiral hypervalent iodine reagents

The ring and I: Hypervalent iodine compounds avoid the issues of toxicity or complicated ligands of many transition-metal-based systems. A highly enantioselective oxyamination of alkenes with N-sulfonyl ureas employing chiral, lactic acid-based hypervalent iodine reagents gives a facile synthesis of enantiomerically pure 2-arylproline derivatives (see scheme) for the first time. Copyright

Concise synthesis of 3-arylpiperidines

We present an easy and straightforward synthesis of 3-arylpiperidines by Grignard addition of piperidin-3-one with different arylmagnesium bromide reagents and acidic dehydroxylation of the resulting tertiary alcohol with the combination of triethylsilane and boron trifluoride etherate. This facile strategy was further used to synthesize preclamol. A highly regioselective dehydration of 3-arylpiperidin-3-ol with boron trifluoride etherate was investigated for preparing 3-aryl-1,4,5,6-tetrahydropyridine skeleton. A novel selenium dioxide mediated dihydroperoxidation of 3-aryl-1,4,5,6-tetrahydropyridine was also examined.