906374-89-8Relevant academic research and scientific papers
Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold
Barluenga, Sofia,Dakas, Pierre-Yves,Ferandin, Yoan,Meijer, Laurent,Winssinger, Nicolas
, p. 3951 - 3954 (2007/10/03)
(Chemical Equation Presented) On solid ground: Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid-phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM = ethoxymethyl.
