906448-27-9Relevant academic research and scientific papers
Ligand-Free Palladium-Catalyzed Carbonylative Suzuki Couplings of Vinyl Iodides with Arylboronic Acids under Substoichiometric Base Conditions
Yang, Zhiyuan,Gong, Pei-Xue,Chen, Junjie,Zhang, Jie,Gong, Xu,Han, Wei
supporting information, p. 1207 - 1212 (2021/06/18)
A ligand-free palladium-catalyzed carbonylation of vinyl iodides with arylboronic acids, permitting the synthesis of chalcones and α-branched enones, has been established. This reaction proceeds smoothly at ambient pressure and temperature, and works well even with a substoichiometric amount of base. Importantly, this mild, efficient, and operationally simple protocol is suitable for the late-stage functionalization of an epiandrosterone-derived complex molecule.
Dual Functionalization of α-Monoboryl Carbanions through Deoxygenative Enolization with Carboxylic Acids
Sun, Wei,Wang, Lu,Xia, Chungu,Liu, Chao
supporting information, p. 5501 - 5505 (2018/04/09)
A dual functionalization of 1,1-diborylalkanes through deoxygenative enolization with carboxylic acids was developed. 1,1-Diborylalkanes were activated by MeLi to generate α-monoboryl carbanions. In situ IR spectroscopy indicated an interaction between carboxylic acid and 1,1-diborylalkane before addition of the activation reagent. Release of the active α-monoboryl carbanion from the masked form was necessary for its reaction with carboxylate to afford enolate species. Electrophilic trapping of enolate species with various electrophiles achieved dual functionalization of 1,1-diborylalkanes to afford a variety of α-mono, di-, and tri-substituted ketones.
A preparation method of the organic compound (by machine translation)
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Paragraph 0115; 0127, (2018/09/08)
The invention relates to a preparation method of the organic compound: comprising the following steps: step one: in the nitrogen atmosphere, are added to the organic solvent in the organic carboxylic acid compound with the [...] compound; step two: to a mixture obtained in the step of adding alkyl lithium reagent, after reaction, is restored to the room temperature; step three: step b by heating the reaction mixture; step four: to step three by the electrophilic reagent is added in the mixture, to continue to reaction to obtain the ketone compound; wherein the organic carboxylic acid compound, alkyl lithium reagent, [...] compound and electrophilic reagents of the amount-of-substance ratio of 1.0: 2.5: 1.5: (1.0 - 2.0). The invention in a simple, economic, easy to obtain the raw material of the substrate, with only the addition of alkyl lithium as the activating agent, does not need any catalyst, a step to construct the previous method is difficult to efficient implementation of the ketone compound compound, such compound in the medical synthetic intermediates and organic photoelectric material science in very great application prospect. (by machine translation)
A direct synthesis of α-(hydroxymethyl) and α-alkyl-vinyl alkyl ketones
Kra?em, Jihène Ben,Ayed, Ta?cir Ben,Amri, Hassen
, p. 7077 - 7079 (2007/10/03)
Reaction of 2,4-diketoesters 3a-c with aqueous formaldehyde using potassium carbonate solution as base affords the corresponding α-methylene-β-hydroxyalkanones 4a-c which provide a route to α,β-unsaturated alkyl ketones 6a-e via coupling of α-acetoxymethy
