91962-95-7

Upstream product

• 15121-79-6 2-(hydroxymethyl)-1-phenylprop-2-en-1-one 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 22731-65-3 2-ethyl-1-phenylprop-2-en-1-one 
• 354529-98-9 1-phenyl-2-propyl-2-propen-1-one 
• 906448-27-9 1-phenyl-2-(2-phenylethyl)prop-2-en-1-one 
• 354529-99-0 1-phenyl-2-butyl-2-propen-1-one 

Relevant academic research and scientific papers

A direct synthesis of α-(hydroxymethyl) and α-alkyl-vinyl alkyl ketones

Reaction of 2,4-diketoesters 3a-c with aqueous formaldehyde using potassium carbonate solution as base affords the corresponding α-methylene-β-hydroxyalkanones 4a-c which provide a route to α,β-unsaturated alkyl ketones 6a-e via coupling of α-acetoxymethy

Acid Promoted Direct Cross-Coupling of Methyl Ketones with Dimethyl Sulfoxide: Access to Ketoallyl Methylsulfides and -sulfones

A new strategy to prepare β-acyl allylic methylsulfides and -sulfones through acid promoted direct cross-coupling of methyl ketones with dimethyl sulfoxide (DMSO) is reported. The reaction proceeded through the nucleophilic attack of enamine intermidiates derived from ketones to in situ generated thionium ion species, followed by elimination of methanthiol to give ketoallylic methylsulfides. With the prolonged reaction time, such products could be further reacted with a methyl sulfonyl radical, which might be generated from a methylthiosulfonate species, to afford ketoallylic methylsulfones in high yields. Molecular transformations of the allylic methylsulfides were also demonstrated.