906448-60-0

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 906448-57-5 (S)-(4-methoxyphenyl)[(2R)-oxiran-2-yl]methanol 
• 906448-59-7 (2S)-2[(R)-azido(4-methoxyphenyl)methyl]oxirane 

Downstream Products

• 635313-41-6 (2S,3R)-3-tert-butoxycarbonylamino-1,2-O-isopropylidene-3-p-methoxyphenyl-1,2-propanediol 
• 220736-25-4 (4R,5S)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Co(iii)(salen)-catalyzed HKR of two stereocentered alkoxy- and azido epoxides: A concise enantioselective synthesis of (S,S)-reboxetine and (+)-epi-cytoxazone

The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S,S)-reboxetine and (+)-epi-cytoxazone.

Asymmetric synthesis of (+)-epi-cytoxazone

The asymmetric synthesis of (+)-epi-cytoxazone, a stereoisomer of potent cytokine modulator cytoxazone, starting from anisaldehyde in six steps, is described. The required configuration was established via Sharpless kinetic resolution followed by the Mits