906532-26-1

Basic information

• Product Name: 3-(N,N-diisopropylamino)-1-phenylpropan-1-ol
• Synonyms: 3-(N,N-diisopropylamino)-1-phenylpropan-1-ol
• CAS NO: 906532-26-1
• Molecular Weight: 235.37
• Mol File: 906532-26-1.mol

Chemical Properties

• CAS DataBase Reference: 3-(N,N-diisopropylamino)-1-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N,N-diisopropylamino)-1-phenylpropan-1-ol(906532-26-1)
• EPA Substance Registry System: 3-(N,N-diisopropylamino)-1-phenylpropan-1-ol(906532-26-1)

Safety Data

• Hazardous Substances Data: 906532-26-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 108-18-9 diisopropylamine 
• 98-86-2 acetophenone 
• 1055330-27-2 3-hydroxy-3-phenylpropyl 4-nitrobenzene sulfonate 
• 51699-49-1 3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate 
• 4850-49-1 1-phenyl-1,3-propanediol 
• 290362-27-5 3-hydroxy-3-phenylpropyl methanesulfonate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 
• 124937-51-5 (R)-(+)-tolterodine 
• 214601-16-8 N,N-diisopropyl-3-(2-hydroxy-5-methyloxycarbonylphenyl)-3-phenylpropanamine 
• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 286930-02-7 fesoterodine 
• 1294517-18-2 methyl 3-(3-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoate (-)-2,3-dibenzoyl-L-tartaric acid salt 
• 1294517-15-9 methyl (R)-(-)-3-(3-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoate 2,3-dibenzoyl-D-tartaric acid salt 
• 906532-18-1 diisopropyl-(3-phenyl-3-p-toluyloxypropyl)amine 
• 1294517-21-7 C₁₀H₁₆O₄S*C₂₃H₃₁NO₃ 
• 200801-70-3 RS-N,N-diisopropyl-3-(2-hydroxy-5-(hydroxymethyl)phenyl)-3-phenylpropylamine 
• 260389-90-0 5-hydroxymethyl tolterodine 
• 214601-16-8 (R)-(-)-3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzoic acid methyl ester 

Relevant articles and documents

Synthetic Method of Intermediate for Fesoterodine

The present invention relates to a method for producing 3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy benzenemethanol, which is an intermediate product useful for producing fesoterodine, by using ethyl benzoylacetate as a starting material. The producin

Formal synthesis of fesoterodine by acid-facilitated aromatic alkylation

The competitive muscarinic receptor antagonist fesoterodine is a congener of tolterodine and has better efficiency compared to tolterodine. In this study, we present an efficient synthesis of the fesoterodine intermediate 3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzaldehyde from ethyl benzoylacetate by Friedel-Crafts alkylation in the presence of an acid as a key reaction step. The synthesis is carried out by the reduction of the ketoester to a 1,3-diol, diisopropylamine substitution, and Friedel-Crafts alkylation, followed by reduction and chiral resolution.

Rearrangement of ethers: A new route to tolterodine

The rearrangement of benzyl phenolic ether in the presence of an acid or AlCl3 is utilized to produce biphenyl methane compounds in very good yields. The synthesis of muscarine receptor antagonist tolterodine is described.

Selective nosylation of 1-phenylpropane-1,3-diol and perchloric acid mediated Friedel-Crafts alkylation: Key steps for the new and straightforward synthesis of tolterodine

We have developed a new and straightforward synthesis of racemic tolterodine [N,N-diisopropyl-3-(2-hydroxy-5-methyl-phenyl)-3-phenylpropanamine]. The synthesis involves selective nosylation on the primary alcohol of 1-phenylpropane-1,3-diol using 4-nitrob

PROCESS FOR PREPARATION OF 3-(2-HYDROXY-5-SUBSTITUTED PHENYL)-N-ALKYL-3-PHENYLPROPYLAMINES

A new process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N,alkyl-3- phenylpropylamiηes from cinamoyl chloride via N-alky-3-phenylprop-2-en-1 -amine has been developed.