90656-99-8

Basic information

• Product Name: (S)-N-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-benzamide
• Synonyms: (S)-N-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-benzamide
• CAS NO: 90656-99-8
• Molecular Weight: 301.773
• Mol File: 90656-99-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (S)-N-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-benzamide(90656-99-8)
• EPA Substance Registry System: (S)-N-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-benzamide(90656-99-8)

Safety Data

• Hazardous Substances Data: 90656-99-8(Hazardous Substances Data)

Upstream product

• 3081-24-1 H-Phe-OEt 
• 593-71-5 Chloroiodomethane 
• 2566-22-5 N-benzoyl-L-phenylalanine 

Downstream Products

• 6163-66-2 2,2'-oxybis(2-methyl-propane) 
• 96922-75-7 (S)-1-[(S)-2-((2R,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butylamino)-propionyl]-pyrrolidine-2-carboxylic acid; hydrochloride 
• 96922-75-7 (S)-1-[(S)-2-((2S,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butylamino)-propionyl]-pyrrolidine-2-carboxylic acid; hydrochloride 
• 103225-20-3 (S)-1-{(S)-2-[((S)-3-Benzoyl-4-benzyl-2,2-dimethyl-oxazolidin-5-ylmethyl)-benzyloxycarbonyl-amino]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 103225-19-0 (S)-2-[((S)-3-Benzoyl-4-benzyl-2,2-dimethyl-oxazolidin-5-ylmethyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-22-5 (S)-2-[((2R,3S)-2-Acetoxy-3-benzoylamino-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-18-9 (S)-2-[((2S,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-18-9 (S)-2-[((2R,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-16-7 (S)-2-[((2R,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid tert-butyl ester 
• 103225-16-7 (S)-2-[((2S,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid tert-butyl ester 
• 92663-50-8 N-{2-Oxo-1-[1-phenyl-meth-(E)-ylidene]-propyl}-benzamide 

Relevant articles and documents

Rh(iii)-Catalyzed diastereoselective transfer hydrogenation: An efficient entry to key intermediates of HIV protease inhibitors

A highly efficient diastereoselective transfer hydrogenation of α-aminoalkyl α′-chloromethyl ketones catalyzed by a tethered rhodium complex was developed and successfully utilized in the synthesis of the key intermediates of HIV protease inhibitors. With the current Rh(iii) catalyst system, a series of chiral 3-amino-1-chloro-2-hydroxy-4-phenylbutanes were produced in excellent yields and diastereoselectivities (up to 99% yield, up to 99?:?1 dr). Both diastereomers of the desired products could be efficiently accessed by using the two enantiomers of the Rh(iii) catalyst.

CERTAIN ACYCLIC, ALICYCLIC, AROMATIC OR HETEROCYCLIC DERIVATIVES OF 3-BENZOYLAMINO-2-OXO- BUTYL-AMINO-CARBONYL-OXY-3-PROPANOIC ACIDS, ESTERS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR ENKEPHALINASE INHIBITING PROPERTIES

Compounds of the formula STR1 wherein Y is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of R 1 may also be useful as analgesics due to their enkepahlinase inhibition activity.

HYDROXY SUBSTITUTED PEPTIDE COMPOUNDS

Hydroxy substituted peptide compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.