90656-99-8

Upstream product

• 3081-24-1 H-Phe-OEt 
• 593-71-5 Chloroiodomethane 
• 2566-22-5 N-benzoyl-L-phenylalanine 

Downstream Products

• 92663-50-8 N-{2-Oxo-1-[1-phenyl-meth-(E)-ylidene]-propyl}-benzamide 
• 103225-16-7 (S)-2-[((2S,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid tert-butyl ester 
• 103225-16-7 (S)-2-[((2R,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid tert-butyl ester 
• 103225-18-9 (S)-2-[((2S,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-18-9 (S)-2-[((2R,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-22-5 (S)-2-[((2R,3S)-2-Acetoxy-3-benzoylamino-4-phenyl-butyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-19-0 (S)-2-[((S)-3-Benzoyl-4-benzyl-2,2-dimethyl-oxazolidin-5-ylmethyl)-benzyloxycarbonyl-amino]-propionic acid 2-trimethylsilanyl-ethyl ester 
• 103225-20-3 (S)-1-{(S)-2-[((S)-3-Benzoyl-4-benzyl-2,2-dimethyl-oxazolidin-5-ylmethyl)-benzyloxycarbonyl-amino]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 96922-75-7 (S)-1-[(S)-2-((2S,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butylamino)-propionyl]-pyrrolidine-2-carboxylic acid; hydrochloride 
• 96922-75-7 (S)-1-[(S)-2-((2R,3S)-3-Benzoylamino-2-hydroxy-4-phenyl-butylamino)-propionyl]-pyrrolidine-2-carboxylic acid; hydrochloride 
• 6163-66-2 2,2'-oxybis(2-methyl-propane) 

Relevant academic research and scientific papers

Rh(iii)-Catalyzed diastereoselective transfer hydrogenation: An efficient entry to key intermediates of HIV protease inhibitors

A highly efficient diastereoselective transfer hydrogenation of α-aminoalkyl α′-chloromethyl ketones catalyzed by a tethered rhodium complex was developed and successfully utilized in the synthesis of the key intermediates of HIV protease inhibitors. With the current Rh(iii) catalyst system, a series of chiral 3-amino-1-chloro-2-hydroxy-4-phenylbutanes were produced in excellent yields and diastereoselectivities (up to 99% yield, up to 99?:?1 dr). Both diastereomers of the desired products could be efficiently accessed by using the two enantiomers of the Rh(iii) catalyst.

ACYLAMINOALKANOYL URETHANES OR THIOURETHANES

Compounds of the formula STR1 wherein Z is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analges

CERTAIN ACYCLIC, ALICYCLIC, AROMATIC OR HETEROCYCLIC DERIVATIVES OF 3-BENZOYLAMINO-2-OXO- BUTYL-AMINO-CARBONYL-OXY-3-PROPANOIC ACIDS, ESTERS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR ENKEPHALINASE INHIBITING PROPERTIES

Compounds of the formula STR1 wherein Y is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of R 1 may also be useful as analgesics due to their enkepahlinase inhibition activity.

HYDROXY SUBSTITUTED UREIDO AMINO AND IMINO ACIDS

Compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase

HYDROXY SUBSTITUTED PEPTIDE COMPOUNDS

Hydroxy substituted peptide compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

ACYLAMINO OXO OR HYDROXY SUBSTITUTED ALKYLAMINO THIAZINES AND THIAZEPINES

Compounds of the formula STR1 and X is an oxo substituted thiazine or thiazepine are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.

SUBSTITUTED PEPTIDE COMPOUNDS

Substituted peptide compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

LACTAM CONTAINING COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE

Compounds of the formula STR1 are disclosed wherein R is STR2 The compounds possess hypotensive activity.