90680-28-7

Basic information

• Product Name: Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]-
• CAS NO: 90680-28-7
• Molecular Formula: C12H9NO3S2
• Molecular Weight: 279.34
• Mol File: 90680-28-7.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]-(90680-28-7)
• EPA Substance Registry System: Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]-(90680-28-7)

Safety Data

• Hazardous Substances Data: 90680-28-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure and functional groups allow it to be a key component in the development of new drugs with potential applications in treating a range of diseases.
Used in Agrochemical Industry:
In the agrochemical sector, Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]is utilized as a precursor in the production of agrochemicals. Its chemical properties make it suitable for the synthesis of pesticides, herbicides, and other crop protection agents, contributing to enhanced agricultural productivity and crop protection.
Used in Chemical Research:
Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]serves as a valuable research compound in the field of organic chemistry. Its distinct structure and functional groups make it an interesting subject for studying chemical reactions, mechanisms, and the development of novel synthetic methodologies.
Used in Material Science:
Ethanone, 1-[4-nitro-5-(phenylthio)-2-thienyl]may also find applications in material science, where its unique structure and properties can be explored for the development of new materials with specific characteristics, such as optoelectronic properties, catalytic activity, or other specialized functions.

Upstream product

• 6310-09-4 2-acetyl-5-chlorothiophene 
• 42456-75-7 5-acetyl-2-chloro-3-nitrothiophene 
• 108-98-5 thiophenol 
• 2160-55-6 1-(5-bromo-4-nitro-thiophen-2-yl)-ethanone 

Relevant articles and documents

Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47

Inhibitors of the cancer-related cysteine isopeptidase human ubiquitin-specific proteases 7 (USP7) and 47 (USP47) are considered to have potential as cancer therapeutics, owing to their ability to stabilize the tumor suppressor p53 and to decrease DNA polymerase β(Polβ), both of which are potential anticancer effects. A new class of dual small molecule inhibitors of these enzymes has been discovered. Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines. Compound 1 has been shown to demonstrate modest activity in human xenograft multiple myeloma and B-cell leukemia in vivo models. This activity may be the result of dual inhibition of USP7 and USP47. To address issues regarding potency and developability, analogues of compound 1 have been synthesized and tested, leading to improvements in potency, solubility, and metabolic reactivity profile. Further optimization is expected to yield preclinical candidates and, ultimately, clinical candidates for the treatment of multiple myeloma, prostate cancer, and other cancers.

Linear Free Energy ortho-Correlations in the Thiophene Series. Part 14. A Kinetic Study of the Benzenethiolate Debromination of Some 2-Bromo-5-nitro-3-X-thiophenes and 2-Bromo-3-nitro-5-X-thiophenes in Methanol.

The study of the title reactions has furnished the following results: i) 3-substituted 2-bromo-5-nitrothiophenes show a good Hammett correlation for X = H, Br, CO2Me, SO2Me, Ac, CN,and NO2, ii) 3-methyl substituent causes a moderate activating effect (ks