906816-49-7

Upstream product

• 906816-50-0 (R,R)-6-chloro-3-phenylindanol 
• 14548-38-0 6-chloro-1-indanone 
• 1374854-32-6 6-chloro-3-phenyl-1H-inden-1-one 
• 1374854-31-5 2-bromo-6-chloro-3-phenylindanone 
• 65565-15-3 6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 1416227-13-8 Trifluoromethanesulfonic acid 4-chloro-2-((E)-(3-phenyl-acryloyl))-phenyl ester 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Ir-catalyzed asymmetric hydrogenation of 3-arylindenones for the synthesis of chiral 3-arylindanones

An efficient synthesis of chiral 3-arylindanones via iridium-catalyzed asymmetric hydrogenation of 3-arylindenones has been developed. The reaction showed good compatibility with various functional groups, delivering a variety of 3-arylindanones in excellent yields and with good enantioselectivities. The reaction was also carried out on a gram-scale, delivering the product in quantitative yield. In addition, the products can be easily derivatized and transformed into natural products and pharmaceutical agents.

HALOGENATED INDENONES AND METHOD FOR PRODUCING OPTICALLY ACTIVE INDANONES OR OPTICALLY ACTIVE INDANOLS BY USING SAME

An optically active ketone represented by the following formula (2): wherein, Ar1 represents a furyl group, a thienyl group or a C6-20 aryl group; X1 represents a halogen atom, and * indicates an asymmetric carbon atom, is

DEUTERATED 1-PIPERAZINO-3-PHENYL-INDANES FOR TREATMENT OF SCHIZOPHRENIA

The present invention relates to deuterated 1-piperazino-3- phenyl-indanes and salts thereof with activity at dopamine receptors D1 and D2 as well as the 5HT2 receptors in the central nervous system, to medicaments comprising such compounds as active ingredients, to the use of such compounds in the treatment of diseases in the central nervous system, and to methods of treatment comprising administration of such compounds.

PROCESS FOR MAKING TRANS-1-((1R, 3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3, 3-DIMETHYLPIPERAZINE

Described is a method for making the trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine (formula I) and salts thereof and a similar method for making 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine (formula IX) and salt