14548-38-0

Basic information

• Product Name: 6-CHLORO-1-INDANONE 96
• Synonyms: 6-CHLORO-1-INDANONE 96;6-Chloro-2,3-dihydro-1H-inden-1-one;6-Chloro-1-indanone;6-choroindanone;1H-Inden-1-one, 6-chloro-2,3-dihydro-;6-Chloro-1-indanone, 97+%
• CAS NO: 14548-38-0
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.6
• EINECS: 1312995-182-4
• Product Categories: API intermediates;Building Blocks;C9;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks
• Mol File: 14548-38-0.mol
• Article Data: 25

Chemical Properties

• Melting Point: 71-79 °C
• Boiling Point: 276.1 °C at 760 mmHg
• Flash Point: 124.6 °C
• Appearance: /
• Density: 1.312 g/cm³
• Vapor Pressure: 0.00489mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 6-CHLORO-1-INDANONE 96(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-1-INDANONE 96(14548-38-0)
• EPA Substance Registry System: 6-CHLORO-1-INDANONE 96(14548-38-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 14548-38-0(Hazardous Substances Data)

Usage

General Description

6-Chloro-1-indanone 96 is a chemical compound with the molecular formula C9H7ClO. It is a white to off-white solid substance that is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 6-CHLORO-1-INDANONE 96 is a chlorinated derivative of 1-indanone, which is a key intermediate in the production of several important compounds. 6-Chloro-1-indanone 96 is known for its high stability and reactivity in organic synthesis, making it a valuable tool for the production of a wide range of chemical products. It is important to handle this chemical with caution, as it can be harmful if ingested or inhaled, and can cause skin and eye irritation upon contact.

InChI:InChI=1/C9H7ClO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2

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Relevant articles and documents

Synthesis and biological evaluation of 9-oxo-9hindeno[1,2-b]pyrazine-2,3- dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes

High-throughput screening highlighted 9-oxo-9H-indeno[1,2-b]pyrazine-2,3- dicarbonitrile (1) as an active inhibitor of ubiquitin-specific proteases (USPs), a family of hydrolytic enzymes involved in the removal of ubiquitin from protein substrates. The chemical behavior of compound 1 was examined. Moreover, the synthesis and in vitro evaluation of new compounds, analogues of 1, led to the identification of potent and selective inhibitors of the deubiquitinating enzyme USP8.

Synthesis and anticancer activity of some 1H-inden-1-one substituted (Heteroaryl)acetamide derivatives

Background: The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer activity were studied. Methods: 2-(3/4-Hydroxybenzylidene)-6-substituted-2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-chloroacetamides to give 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene) methyl)phenoxy]-N-(heteroaryl)acetamide derivatives. Results: The structure elucidation of the newly synthesised 16 compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Conclusion: Compound 3e (2-(3-((6-chloro-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl)phenoxy)-N-(thiazol-2-yl)acetamide), exhibited highest growth inhibition against the leukaemia (61.47%), non-small cell lung cancer (79.31%) and breast cancer (62.82%) cell lines.

CARBAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a carbamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.