90701-94-3

Upstream product

• 90709-17-4 (E)-5-iodomethylene-2-phenyl-4,5-dihydro-oxazolium periodide 
• 1464-98-8 N-(prop-2-yn-1-yl)benzamide 

Downstream Products

• 92629-13-5 2?phenyloxazole?5?carbaldehyde 
• 106833-79-8 2-phenyl-1,3-oxazole-5-carboxylic acid 
• 238433-75-5 2-phenyl-5-(hydroxymethyl)oxazole 

Relevant academic research and scientific papers

Preparation of oxazolines and oxazoles via a PhI(OAc)2-promoted cyclization of N-propargylamides

A metal-free cyclization of N-propargylamides for the synthesis of various oxazolines and oxazoles via a 5-exo-dig process is presented. Using (diacetoxyiodo)benzene (PIDA) as a reaction promoter and lithium iodide (LiI) as an iodine source, intramolecula

2,4-Imidazolinedione heterocyclic derivative, and preparation method and use thereof

The invention belongs to the field of chemical medicines, and concretely relates to a 2,4-imidazolinedione heterocyclic derivative, and a preparation method and a use thereof. The structure of the 2,4-imidazolinedione heterocyclic derivative is represented by formula I. The invention also provides the preparation method and the use of the 2,4-imidazolinedione heterocyclic derivative. The 2,4-imidazolinedione heterocyclic derivative has a good inhibition effect on Pim-1 protein kinase micro-molecules, and has important exploitation application prospect.

From propargylamides to oxazole derivatives: NIS-mediated cyclization and further oxidation by dioxygen

NIS-mediated iodocyclization of N-sulfonyl propargylamides for the synthesis of various oxazolidines and iodoalkylidenedihydrooxazoles via a 5-exo-dig process is developed. The resulting iodoalkylidenedihydrooxazoles can be further transformed into the corresponding oxazoles in the presence of dioxygen.

Cyclization of propargylic amides: Mild access to oxazole derivatives

The substrate scope, the mechanistic aspects of the gold-catalyzed oxazole synthesis, and substrates with different aliphatic, aromatic, and functional groups in the side chain were investigated. Even molecules with several propargyl amide groups could easily be converted, delivering di- and trioxazoles with interesting optical properties. Furthermore, the scope of the gold(I)-catalyzed alkylidene synthesis was investigated. Further functionalizations of these isolable intermediates of the oxazole synthesis were developed and chelate ligands can be obtained. The use of Barluenga's reagent offers a new and mild access to the synthetically valuable iodoalkylideneoxazoles from propargylic amides, this reagent being superior to other sources of halogens.

Intramolecular Cyclisation Using Methyl(bismethylthio)sulphonium Salts, Bromine, and Iodine. 5-Methylene-4,5-dihydro-oxazoles from 3-amidopropynes

The reaction of methyl(bismethylthio)sulphonium hexachloroantimonate (3) with acylaminopropines (1) and (2) gave (E)-5-methylthiomethylene-2-phenyl-4,5-dihydro-oxazolium (4) and (E)-2-methyl-5-methylthiomethylene-4,5-dihydro-oxazolium (7) hexachloroantimo

NEIGHBOURING GROUP PARTICIPATION IN ELECTROPHILIC ADDITION TO ACETYLENES. 5-METHYLENE OXAZOLINES FROM 3-BENZAMIDOPROPYNE.

Benzamido group participates in addition of various electrophiles to triple bond leading to 5-methylene oxazolines.