238433-75-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
(2-Phenyloxazol-5-yl)Methanol is used as a reagent and building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups contribute to the development of new and effective compounds in these industries.
Used in Drug Discovery and Development:
(2-Phenyloxazol-5-yl)Methanol is used as a subject of interest in drug discovery and development due to its demonstrated potential pharmacological activities. Its ability to interact with biological targets and modulate biological pathways makes it a promising candidate for the development of new therapeutic agents.
Used in Coordination Chemistry:
(2-Phenyloxazol-5-yl)Methanol is used as a ligand in coordination chemistry, contributing to the understanding of its role in metal ion binding and catalytic processes. Its coordination properties allow for the exploration of its potential applications in catalysis, sensing, and other areas of chemistry.

Upstream product

• 1464-98-8 N-(prop-2-yn-1-yl)benzamide 
• 146896-52-8 2-phenyl-5-methylene-4,5-dihydrooxazole 
• 626-35-7 nitroacetic acid ethyl ester 
• 92629-13-5 2?phenyloxazole?5?carbaldehyde 
• 90701-94-3 (E)-5-(iodomethylene)-2-phenyl-4,5-dihydrooxazole 
• 98-88-4 benzoyl chloride 
• 1391708-74-9 5-(hydroperoxymethyl)-2-phenyloxazole 
• 39819-40-4 ethyl 2-phenyloxazole-5-carboxylate 

Downstream Products

• 263549-84-4 diethyl 2-(2-phenyloxazol-5-yl)methylenemalonate 
• 263549-83-3 (E)-3-(2-phenyloxazol-5-yl)propenoic acid 
• 92629-13-5 2?phenyloxazole?5?carbaldehyde 

Relevant academic research and scientific papers

Preparation of oxazolines and oxazoles via a PhI(OAc)2-promoted cyclization of N-propargylamides

A metal-free cyclization of N-propargylamides for the synthesis of various oxazolines and oxazoles via a 5-exo-dig process is presented. Using (diacetoxyiodo)benzene (PIDA) as a reaction promoter and lithium iodide (LiI) as an iodine source, intramolecula

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

We report here on the use of ethyl nitroacetate as a glycine template to produce α-amino esters. This started with a study of its condensation with various arylacetals to give ethyl 3-aryl-2-nitroacrylates followed by a reduction (NaBH4 and then zinc/HCl) into α-amino esters. The scope of this method was explored as well as an alternative with arylacylals instead. We also focused on various [2 + 3] cycloadditions, one leading to a spiroacetal, which led to the undesired ethyl 5-(benzamidomethyl)isoxazole-3-carboxylate. The addition of ethyl nitroacetate on a 5-methylene-4,5-dihydrooxazole using cerium(IV) ammonium nitrate was also explored and the synthesis of other oxazole-bearing α-amino esters was achieved using gold(I) chemistry.

Safe and Fast Flow Synthesis of Functionalized Oxazoles with Molecular Oxygen in a Microstructured Reactor

The synthesis of hydroperoxymethyl oxazoles by oxidation of alkylideneoxazoles with molecular oxygen was implemented in a microstructured reactor for increased safety and larger-scale applications. Elaborate studies on the influence of pressure and temper

From propargylic amides to functionalized oxazoles: Domino gold catalysis/oxidation by dioxygen

A new, highly efficient, and atom-economic access to a series of functionalized 2,5-disubstituted oxazoles from propargylic amides is reported. A series of propargylic amides were transformed to the corresponding alkylideneoxazolines by a gold(I) catalyst. The next step was an autoxidation to hydroperoxides bearing the heteroaromatic oxazoles. Experiments addressing the reaction mechanism reveal a radical pathway for this autoxidation process. The hydroperoxides could conveniently be converted to the corresponding alcohols by reduction with sodium borohydride.

The synthesis and activity of oxazole and thiazole analogues of urocanic acid

Direct exposure of human skin to sunlight leads to suppression of the immune system, believed to be mediated by urocanic acid. The synthesis of oxazole and thiazole analogues of urocanic acid is reported, as is their effect on biological markers of the hu