92629-13-5

Basic information

• Product Name: 2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE
• Synonyms: 2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE;2-Phenyloxazole-5-carbaldehyde
• CAS NO: 92629-13-5
• Molecular Formula: C₁₀H₇NO₂
• Molecular Weight: 173.17
• Mol File: 92629-13-5.mol
• Article Data: 23

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE(92629-13-5)
• EPA Substance Registry System: 2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE(92629-13-5)

Safety Data

• Hazardous Substances Data: 92629-13-5(Hazardous Substances Data)

Usage

General Description

2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE is a chemical compound with a molecular formula C11H9NO2. It belongs to the oxazole class of chemicals and is commonly used in organic synthesis and pharmaceutical research. 2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE is a benzaldhyde derivative with a substituted oxazole ring, making it a versatile building block for the synthesis of various pharmaceuticals and agrochemicals. It has been widely studied for its potential medicinal properties, including its antifungal and antibacterial activities. Additionally, 2-PHENYL-1,3-OXAZOLE-5-CARBALDEHYDE has potential applications as a fluorescent probe in biological imaging and as a marker for various enzyme assays.

InChI:InChI=1/C10H7NO2/c12-7-9-6-11-10(13-9)8-4-2-1-3-5-8/h1-7H

Upstream product

• 20662-88-8 2-phenyloxazole 
• 68-12-2 N,N-dimethyl-formamide 
• 238433-75-5 2-phenyl-5-(hydroxymethyl)oxazole 
• 1464-98-8 N-(prop-2-yn-1-yl)benzamide 
• 92629-11-3 5-bromo-2-phenyl-1,3-oxazole 
• 90701-94-3 (E)-5-(iodomethylene)-2-phenyl-4,5-dihydrooxazole 
• 591-50-4 iodobenzene 
• 93-89-0 benzoic acid ethyl ester 
• 18838-10-3 N-(2-hydroxyethyl)-benzamide 
• 7127-19-7 2-phenyl-1,3-oxazoline 
• 39819-40-4 ethyl 2-phenyloxazole-5-carboxylate 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 106833-79-8 2-phenyl-1,3-oxazole-5-carboxylic acid 
• 263549-83-3 (E)-3-(2-phenyloxazol-5-yl)propenoic acid 
• 263549-84-4 diethyl 2-(2-phenyloxazol-5-yl)methylenemalonate 
• 39819-42-6 amide of 2-phenyloxazole-5-carboxylic acid 
• 106833-83-4 methyl 2-phenyl-1,3-oxazole-5-carboxylate 
• 106833-92-5 2'-Phenyl-2,5'-bioxazole 
• 106833-86-7 4,5-Dihydro-2'-phenyl-2,5'-bioxazole 
• 106833-87-8 N-(2-Hydroxyethyl)amide of 2-phenyloxazole-5-carboxylic acid 
• 238433-75-5 2-phenyl-5-(hydroxymethyl)oxazole 

Relevant articles and documents

Iodine-mediated aminohalogenation-oxidation to synthesize 2-fluoroalkyl imidazole derivatives

A simple and efficient method of iodine-mediated aminohalogenation-oxidation of fluorinated N’-propargyl amidines to synthesize 2-fluoroalkyl imidazole-5-carbaldehydes was developed. This method showed good functional group compatibility and wide substrat

Versatile Photochemical Reactivity of Diverse Substituted 2-, 4- and 5-(o-Vinylstyryl)oxazoles

To study the effects of the position of the hexatrienyl moiety on the oxazole ring, novel substituted cis/trans-2/4/5-(2-vinylstyryl)oxazoles have been synthesized. These novel compounds were prepared by Wittig reaction from the diphosphonium salt of α,α′-o-xylenedibromide, formaldehyde and the corresponding 2-methyl-4-, 4-methyl-2-, 2-pheny-5- and 4-methyl-5-oxazolecarbaldehyde, respectively. Aldehydes were synthesized by using several synthetic approaches. By applying intramolecular photocycloaddition, 2-methyl-4-(2-vinylstyryl)oxazole afforded, as major product, fused oxazoline-benzobicyclo[3.2.1]octene with small quantities of 4-(1,2-dihydronaphthalen-2-yl)-2-methyloxazole, as electrocyclization product. Upon irradiation of 4-methyl-5-(2-vinylstyryl)oxazole, endo- and exo-benzobicyclo[2.1.1]hexene products were formed by [2+2] cycloaddition; this was the first instance of the 1,4-closure to the bicyclo[2.1.1]hexene skeleton in the 2-, 4-, and 5-oxazole-stilbene derivatives studied so far. Derivatives 2-phenyl-5- and 4-methyl-2-(2-vinylstyryl)oxazole did not react and gave only high-weight molecular products but were crucial as a comparison in the overall mechanistic study. We have found that, depending on the position of the hexatrienyl moiety in the oxazole ring, as well as on the position of the methyl/phenyl substituents, these new vinylstyryl-2/4/5-oxazole derivatives show diverse photochemical behavior.

Preparation of oxazolines and oxazoles via a PhI(OAc)2-promoted cyclization of N-propargylamides

A metal-free cyclization of N-propargylamides for the synthesis of various oxazolines and oxazoles via a 5-exo-dig process is presented. Using (diacetoxyiodo)benzene (PIDA) as a reaction promoter and lithium iodide (LiI) as an iodine source, intramolecula