90741-40-5

Upstream product

• 38854-94-3 N-benzyl-L-pyroglutamic acid 
• 77539-18-5 (S)-(+)-2-benzylamino glutaric acid 
• 100-52-7 benzaldehyde 
• 56-86-0 L-glutamic acid 
• 90741-27-8 (S)-tert-butyl 1-benzyl-5-oxopyrrolidine-2-carboxylate 
• 90741-33-6 (2S)-1-benzyl-(E)-5-<(methoxycarbonyl)methylidene>proline tert-butyl ester 
• 90741-31-4 (S)-N-benzyl-5-thioxoproline tert-butyl ester 
• 90741-36-9 (2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester 

Downstream Products

• 1056941-54-8 1-benzyl-5-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 1056941-53-7 1-(3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionyl)-5-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 113472-56-3 (2S)-cis-1-(benzyloxycarbonyl)-5-vinylproline tert-butyl ester 
• 182137-38-8 (2S,5R)-5-(2-Bromo-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 178813-40-6 (2S,5R)-5-(2-Hydroxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 182137-69-5 (2S,5R)-5-(2-Phenylselanyl-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 182137-68-4 (2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 182138-57-4 (1S,3S,4R)-3-Triethylsilanyloxy-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester 
• 182266-45-1 (2S,5R)-(R)-5-Oxiranyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 182137-71-9 (2S,5R)-(S)-5-Oxiranyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 182137-73-1 (2S,5R)-5-((S)-2-Bromo-1-triethylsilanyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 182266-46-2 (2S,5R)-5-((R)-2-Bromo-1-triethylsilanyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 162284-66-4 (2S)-cis-1-<2-acetylamino-(Z)-3-phenylacryloyl>-5-(2-phenylselenoethyl)proline tert-butyl ester 
• 162284-65-3 (2S)-cis-1-<2-acetylamino-(Z)-2-butenoyl>-5-(2-phenylselenoethyl)proline tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of 7,5-Fused Bicyclic Lactams by Stereoselective Radical Cyclization

7,5-Fused bicyclic lactams of type 1 were synthesized by a route involving the radical cyclization of the intermediate 2.High level of stereoselection was obtained in this reaction.

A the non-peptide class perishes weakly inhibiting protein antagonists and its synthetic method and application (by machine translation)

This invention discloses a kind of the non-peptide class perishes weakly inhibiting protein antagonist and method for preparing the same and application, which aims to provide a better anticancer effect with the non-peptide class perishes weakly inhibitin

Chirospecific synthesis of conformationally constrained 7-azabicycloheptane amino acids by transannular alkylation

A new method is reported for the chirospecific preparation of optically pure 1-carboxy-7-azabicycloheptane amino acids for the generation of peptidomimetics as conformational probes. The method allows for the multigram preparation of these amino acid analogues through use of a thiolactam sulfide contraction and a transannular alkylation sequence as the key C-C bond-forming steps, starting from L-glutamic acid. The route provides access to two common intermediates, 7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]-3-heptane and (1S,4R)-7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]-3-heptanon e tert-butyl ester, for elaboration to symmetrical and chiral amino acid homologues, respectively. Decarboxylation of the C-1 carboxy unit of the latter intermediate also demonstrated the applicability of the method for a short, chirospecific preparation of a (+)-epibatidine intermediate, (1S,4R)-7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]3-hepta none.