77539-18-5

Basic information

• Product Name: (S)-N-BENZYLGLUTAMIC ACID
• Synonyms: (S)-N-BENZYLGLUTAMIC ACID
• CAS NO: 77539-18-5
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.25
• Mol File: 77539-18-5.mol

Chemical Properties

• Melting Point: 160-162 °C
• Boiling Point: 434.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.270±0.06 g/cm3(Predicted)
• PKA: 2.17±0.10(Predicted)
• CAS DataBase Reference: (S)-N-BENZYLGLUTAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-BENZYLGLUTAMIC ACID(77539-18-5)
• EPA Substance Registry System: (S)-N-BENZYLGLUTAMIC ACID(77539-18-5)

Safety Data

• Hazardous Substances Data: 77539-18-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-N-Benzylglutamic acid is used as a building block for the synthesis of various pharmaceuticals and bioactive compounds. Its unique molecular structure allows for the creation of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
(S)-N-Benzylglutamic acid serves as a research tool in the field of medicinal chemistry, where it is utilized to study the interactions between biological molecules and potential drug candidates. This helps in the development of more effective and targeted therapies.
Used in Biochemistry Research:
In the field of biochemistry, (S)-N-Benzylglutamic acid is employed to investigate the mechanisms of various biological processes and to identify potential targets for therapeutic intervention. Its unique structure and potential biological activity make it a valuable compound for understanding complex biochemical pathways and developing novel therapeutic strategies.

Upstream product

• 56-86-0 L-glutamic acid 
• 100-52-7 benzaldehyde 
• 328-50-7 α-ketoglutaric acid 
• 100-46-9 benzylamine 

Downstream Products

• 90741-40-5 tert-butyl (2R,5R)-1-benzyl-5-(2-hydroxyethyl)pyrrolidine-2-carboxylate 
• 90741-36-9 (2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester 
• 90741-33-6 (2S)-1-benzyl-(E)-5-<(methoxycarbonyl)methylidene>proline tert-butyl ester 
• 90741-31-4 (S)-N-benzyl-5-thioxoproline tert-butyl ester 
• 90741-27-8 (S)-tert-butyl 1-benzyl-5-oxopyrrolidine-2-carboxylate 
• 130607-80-6 (2S,5R)-1-Benzyl-5-((R)-1-benzyloxycarbonyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 130516-29-9 (2S,5R)-1-Benzyl-5-((S)-1-benzyloxycarbonyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 130516-27-7 (S)-1-Benzyl-5-[1-benzyloxycarbonyl-prop-(Z)-ylidene]-pyrrolidine-2-carboxylic acid methyl ester 
• 130516-24-4 (S)-(+)-1-Benzyl-5-thioxoproline methyl ester 
• 132256-86-1 Benzyl-(S)-2,3,5,6,7,8-hexahydro-indolizin-6-yl-carbamic acid benzyl ester 

Relevant articles and documents

Substituted 5-oxo-pyrrolidine derivative, and preparation method and applications thereof

The invention belongs to the technical field of medicine, relates to a substituted 5-oxo-pyrrolidine derivative disclosed in generation formula I, and a preparation method and applications thereof, and more specifically relates to applications of the substituted 5-oxo-pyrrolidine derivative in preparation of anti-cerebral ischemia medicines as a nerve protective agent, and a pharmaceutical composition taking the substituted 5-oxo-pyrrolidine derivative and a pharmaceutically acceptable salt of the substituted 5-oxo-pyrrolidine derivative as active components. The pharmaceutical composition contains the substituted 5-oxo-pyrrolidine derivative and a pharmaceutical excipient and/or a diluent of the substituted 5-oxo-pyrrolidine derivative. In the general formula I, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Y, and n are defined in the patent specification and patent claims.

A the non-peptide class perishes weakly inhibiting protein antagonists and its synthetic method and application (by machine translation)

This invention discloses a kind of the non-peptide class perishes weakly inhibiting protein antagonist and method for preparing the same and application, which aims to provide a better anticancer effect with the non-peptide class perishes weakly inhibitin

An efficient and straight forward strategy for the synthesis of enantiomerically pure (S)-1-benzyl-5-(alkyl/aryl amino) methyl-pyrrolidin-2-ones

A simple, efficient and straightforward strategy for the synthesis of enantiomerically pure (S)-5-((alkyl/aryl amino) methyl)-pyrrolidin-2-ones from N-benzyl-5(S)-pyroglutaminol through Mitsunobu reaction has been described. These pyrrolidin-2-ones have great potential to act as asymmetric precursors for the synthesis of bioactive compounds/ natural products requiring suitably substituted aminomethyl group at C-5 of native pyrrolidin-2-ones.

Electrophilic Amination of Amino Acids with N-Boc-oxaziridines: Efficient Preparation of N-Orthogonally Diprotected Hydrazino Acids and Piperazic Acid Derivatives

A general two-step preparation of enantiopure Nα,N β-orthogonally diprotected α-hydrazino acids 1 is developed on a multigram scale. The key reaction is the efficient electrophilic amination of N-benzyl amino acids 6 with N-Boc-oxaziridine 7 and accommodates various functional groups encountered in side chains of amino acids. The cyclic 2,3,4,5-tetrahydro-3-pyridazine carboxylic acid (piperazic acid) derivatives 2 and 3 or the cyclic 3,4-dihydro-3-pyrazolecarboxylate 4 are conveniently prepared from glutamic acid or aspartic acid via orthogonally diprotected α-hydrazino acids 1m and 1n.

The first highly enantioselective homogeneously catalyzed asymmetric reductive amination: Synthesis of α-N-benzylamino acids

High-throughput screening considering a library of 96 chiral P-ligands involved in two types of RhI complexes was used for the identification of homogeneous catalysts for the highly enantioselective reductive amination of α-keto acids with benzylamine. After optimization of the reaction conditions and scale-up with a cationic Rh-Deguphos catalyst, a range of chiral α-amino acids could be produced by this new reaction in good yield and by up to 98% ee.

Sodium borohydride: A versatile reagent in the reductive N-monoalkylation of α-amino acids and α-amino methyl esters

α-Amino acids and α-amino methyl esters are easily converted to their N-monoalkyl derivatives by a reductive condensation reaction using several carbonyl compounds in the presence of sodium borohydride. This reducing agent has shown a wide versatility with minor but essential procedural variations. The reaction allows the α-monodeuterium labeling of the new N-substituent by use of sodium borodeuteride.

The improved synthesis of enantiopure (s)-N-arylmethyl-5-oxoprolines

A mild procedure for the preparation of enantiopure N-alkylated (S)- (+)-5-oxoprolines 3a-r is described. The method starting from (S)-glutamic acid appears generally applicable to substrates with a wide range of substituents.

Peptide Mimetics of Thyrotropin-Releasing Hormone Based on a Cyclohexane Framework: Design, Synthesis, and Cognition-Enhancing Properties

The design and synthesis of peptide mimetics of thyrotropin-releasing hormone (TRH) in which the peptide backbone is entirely replaced by a cyclohexane framework are described.The cis-1,3,5-trisubstituted ring was expected to permit key pharmacophoric gro

NEW STRATEGY FOR THE CONSTRUCTION OF CARBAPENEMS. TOTAL SYNTHESIS OF 6-epi PS-5 AND PS-5

A strategically novel approach to carbapenems has been developed.The pyrrolidine ring is first constructed, appended with the required side chains, and the β-lactam ring is then annealed.We have demonstrated the utility of the approach to the asymmetric s

AN EFFICIENT ONE-STEP REDUCTIVE N-MONOALKYLATION OF α-AMINO ACIDS

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