1374343-97-1

Basic information

• Product Name: (S,E)-3-(nitromethyl)-5-(4-nitrophenyl)-1-phenylpent-4-en-1-one
• Synonyms: (S,E)-3-(nitromethyl)-5-(4-nitrophenyl)-1-phenylpent-4-en-1-one
• CAS NO: 1374343-97-1
• Molecular Weight: 340.335
• Mol File: 1374343-97-1.mol

Chemical Properties

• CAS DataBase Reference: (S,E)-3-(nitromethyl)-5-(4-nitrophenyl)-1-phenylpent-4-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S,E)-3-(nitromethyl)-5-(4-nitrophenyl)-1-phenylpent-4-en-1-one(1374343-97-1)
• EPA Substance Registry System: (S,E)-3-(nitromethyl)-5-(4-nitrophenyl)-1-phenylpent-4-en-1-one(1374343-97-1)

Safety Data

• Hazardous Substances Data: 1374343-97-1(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 3769-51-5 (E,E)-(4-nitrocinnamalylidene)acetophenone 
• 90771-52-1 1-nitro-4-((1E,3E)-4-nitrobuta-1,3-dienyl)benzene 
• 98-86-2 acetophenone 
• 49678-08-2 3-(4-nitrophenyl)-propenal 
• 3769-51-5 5-(4-nitrophenyl)-1-phenylpenta-2,4-dien-1-one 

Relevant articles and documents

Organocatalytic "difficult" michael reaction of ketones with nitrodienes utilizing a primary amine-thiourea based on Di-tert-butyl aspartate

The primary amine-thiourea based on di-tert-butyl (S)-aspartate and (1R,2R)-1,2-diphenylethylene-1,2-diamine has been successfully employed in the "difficult" Michael reaction between aromatic ketones or acetone with nitrodienes. The high stability and re

Highly enantioselective 1, 4-michael additions of nucleophiles to unsaturated aryl ketones with organocatalysis by bifunctional cinchona alkaloids

The development of general and efficient asymmetric organocatalytic additions of malononitrile and nitromethane to 1, 5-diarylpenta-2, 4-dien-1-ones (cinnamylideneacetophenones) catalyzed by cinchona organocatalysts is reported. The reactions afforded excellent enantioselectivities (up to 99%), high yields (up to 97%), and exclusive 1, 4-addition regioselectivities. The potential of these new enantioselective additions lies in the demonstration that organocatalysts bearing primary amino groups in combination with TFA provide effective catalytic systems for the activation of a broad range of aryl ketones under mild conditions to give compounds with high levels of enantioselectivity and yields.

Highly enantioselective and regioselective conjugate addition of nitromethane to 1,5-diarylpenta-2,4-dien-1-ones using bifunctional cinchona organocatalysts

A general and efficient asymmetric organocatalytic 1,4-Michael addition of nitromethane to 1,5-diarylpenta-2,4-dien-1-ones (cinnamylideneacetophenones) catalyzed by 9-thiourea-9-(deoxy)-epi-hydroquinine has been developed. The reactions afforded excellent enantioselectivities (up to 99%), high yields (up to 97%), and exclusive regioselectivity. Georg Thieme Verlag Stuttgart - New York.