90788-17-3

Upstream product

• 3853-06-3 methyl 3-(dimethylamino)propionate 
• 100-39-0 benzyl bromide 
• 220438-32-4 (S)-(+)-methyl 2-<(trimethylsilyl)methyl>amino-3-phenylpropionate 
• 3070-71-1 methyl 2-benzylacrylate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 196395-19-4 (S)-2-((R)-2-Acetylsulfanylmethyl-3-phenyl-propionylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 182479-25-0 (S)-3-(1H-Indol-3-yl)-2-((S)-2-mercaptomethyl-3-phenyl-propionylamino)-propionic acid methyl ester 
• 182479-27-2 (S)-3-(1H-Indol-3-yl)-2-((R)-2-mercaptomethyl-3-phenyl-propionylamino)-propionic acid methyl ester 

Relevant academic research and scientific papers

Novel isomerization reaction of N,N-dimethyl-α-(methoxycarbonyl)-4- substituted-benzylammonium N-methylides

Fluoride ion-induced desilylation of N,N-dimethyl-N- [(trimethylsilyl)methyl]-α-(methoxycarbonyl)4-substituted benzylammonium salts (7) gave two Stevens rearrangement products: methyl 3-(dimethylamino)- 2-(4-substituted phenyl)propionates (13) from N-methylides 8, and methyl 3- (dimethylamino)-3-(4-substituted phenyl)propionates (15) from N-benzylides 10. Additional Stevens rearrangement products, methyl 2-(dimethylamino)-3- (4-substituted phenyl)propionates (16), were competitively formed from ylides 12 when the cesium fluoride used was not predried. The mechanism of the isomerization from methylides 8, which was initially generated, to 10 and 12 is discussed.

Thiol inhibitors of endothelin-converting enzyme

Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'1 and P'2 residues led to inhibitors with similar potency to that of phosphoramidon.