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Usage

Uses

Used in Organic Synthesis:
Ethyl 2-(2-iodophenyl)acetate is used as a key intermediate in organic synthesis for the production of various compounds. Its unique structure and reactivity make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In pharmaceutical research, Ethyl 2-(2-iodophenyl)acetate is utilized as a starting material for the development of new drugs. Its iodine atom can be easily replaced with other functional groups, allowing for the creation of a wide range of bioactive molecules with potential therapeutic applications.
Used in Fragrance Industry:
Ethyl 2-(2-iodophenyl)acetate is used as a fragrance ingredient in perfumes and personal care products due to its pleasant aroma. Its sweet and fruity scent adds depth and complexity to fragrance formulations, making it a sought-after component in the fragrance industry.
Used in Flavor and Fragrance Production:
In addition to its use in perfumes, Ethyl 2-(2-iodophenyl)acetate is also utilized in the production of flavors and fragrances for the food and beverage industry. Its unique scent profile can enhance the taste and aroma of various products, contributing to a more enjoyable consumer experience.
Used in Chemical Research and Development:
Ethyl 2-(2-iodophenyl)acetate is employed in chemical research and development for the exploration of new reactions and the synthesis of novel compounds. Its versatility and reactivity make it an important tool for chemists working on the cutting edge of chemical science.

Upstream product

• 64-17-5 ethanol 
• 18698-96-9 o-iodophenylacetic acid 
• 40400-13-3 2-Iodobenzyl bromide 
• 615-37-2 ortho-methylphenyl iodide 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 

Downstream Products

• 128823-22-3 (2-iodophenyl)propanedioic acid diethyl ester 
• 868659-67-0 ethyl 2-(2-(phenylethynyl)phenyl)acetate 
• 1095548-84-7 ethyl 2-(2-((3-methoxyphenyl)ethynyl)phenyl)acetate 
• 1095548-81-4 ethyl 2-((2-(naphthalen-2-yl)ethynyl)phenyl)acetate 
• 1095548-87-0 ethyl 2-(2-(3-(benzyloxy)prop-1-ynyl)phenyl)acetate 
• 1417512-55-0 ethyl 2-(2-phenoxyphenyl)acetate 
• 1075683-89-4 ethyl 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-10-carboxylate 
• 1075684-07-9 C₁₅H₁₇NO₄ 
• 154502-70-2 ethyl 2-(2-benzoylphenyl)acetate 
• 1178576-56-1 C₁₂H₁₁NO₂ 
• 1178576-57-2 (R)-3-methyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-b]isoquinoline-10-carboxylic acid ethyl ester 
• 1178576-55-0 C₁₅H₁₇NO₅ 
• 1178576-66-3 3-methyl-9-oxo-1-phenyl-1,2,3,9-tetrahydro-pyrazolo[1,5-b]isoquinoline-4-carboxylic acid ethyl ester 
• 1178576-65-2 9-oxo-1-phenyl-1,2,3,9-tetrahydro-pyrazolo[1,5-b]isoquinoline-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

One-Pot Base-Mediated Synthesis of Functionalized Aza-Fused Polycyclic Quinoline Derivatives

A new one-pot protocol has been developed for the facile and efficient synthesis of aza-fused polycyclic quinolines (e.g., pyrrolo[1,2-a]quinolines) by the base-catalyzed reaction of 2-formylpyrroles and 2-halophenylacetonitriles. This reaction proceeded under transition metal-free conditions and showed high functional group tolerance, with the desired products being formed in good yields.

COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS

The invention relates to novel cycloalkyl- or cycloalkenyl-substituted pyrazolopyrimidinones of formula (I), wherein ā is selected from the group A1 consisting of a C3-C8-cycloalkyl group or a C4-C8-cycloalkenyl group, whereby the members of C3-C8-cycloalkyl group being selected from the group of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptanyl and cyclooctanyl; and the members of the C4-C8-cycloalkenyl group, being selected from cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclopentadienyl, cyclohexadienyl, cycloheptadienyl, cyclooctadienyl, cycloheptatrienyl, cyclooctathenyl, cyclooctatetraenyl. The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving perception, concentration, learning and/or memory in patients in need thereof. Chemically, the compounds are characterised as pyrazolopyrimidinones with a cycloalkyl-moiety directly bound to the 1 position of the pyrazolopyrimidinone and a second substituent in the 6 position which is bound via an optionally substituted methylene-bridge. Further aspects of the present invention refer to a process for the manufacture of the compounds and their use for producing medicaments.

Synthesis of indene derivatives via electrophilic cyclization

3-Iodo-1H-indene derivatives are synthesized by iodonium-promoted 5-endo-dig carbocyclization of 2-substituted ethynylmalonates. Various 2-substituted ethynylmalonates bearing aryl-, alkyl-and ether-protected propargyl alcohols were successfully converted

1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS

The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones, Formula (I) with Hc is a mono-, bi- or tricyclic heterocyclyl group, the ring members of which are carbon atoms and at least 1, preferably 1, 2 or 3, heteroatom(s), which are selected from the group of nitrogen, oxygen and sulphur, which is in the form of -S(O)r - with r being 0, 1 or 2, and - said heterocyclyl group is or comprises 1 non-aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member and - said heterocyclyl group is bound to the scaffold by said 1 non- aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member. According to one aspect of the invention the new compounds are for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments for the treatment of Alzheimer's disease.

Palladium-catalyzed carboxamidation reaction and aldol condensation reaction cascade: A facile approach to ring-fused isoquinolinones

(Chemical Equation Presented) Palladium-catalyzed carboxamidation reaction and aldol condensation reaction cascade are very useful for the synthesis of various ABC ring substituted fused isoquinolinones.

4,6-O-[1-cyano-2-(2-iodophenyl)ethylidene] acetals. Improved second-generation acetals for the stereoselective formation of β-D-mannopyranosides and regioselective reductive radical fragmentation to β-D-rhamnopyranosides. Scope and limitations

The [1-cyano-2-(2-iodophenyl)]ethylidene group is introduced as an acetal-protecting group for carbohydrate thioglycoside donors. The group is easily introduced under mild conditions, over short reaction times, and in the presence of a wide variety of oth

Synthesis of indenes by the palladium-catalyzed carboannulation of internal alkynes

(Chemical Equation Presented) A number of highly substituted indenes have been prepared in good yields by treating functionally substituted aryl halides with various internal alkynes in the presence of a palladium catalyst. The reaction is believed to proceed by regioselective arylpalladation of the alkyne and subsequent nucleophilic displacement of the palladium in the resulting vinylpalladium intermediate.