908111-29-5

Upstream product

• 126-81-8 dimedone 
• 36282-26-5 2-bromo-4-fluorobenzonitrile 
• 16315-16-5 3,6,6-trimethyl-1⁽²⁾,5,6,7-tetrahydro-4H-indazole-4-one 
• 1755-15-3 2-acetyldimedone 
• 263845-82-5 2-bromo-4-hydrazinylbenzonitrile 

Downstream Products

• 1433958-18-9 tert-butyl 4-(((2-carbamoyl-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)methyl)piperidine-1-carboxylate 
• 1433958-17-8 tert-butyl 4-(((2-cyano-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)methyl)piperidine-1-carboxylate 
• 1073973-19-9 2-[1-(2-benzyloxy-ethyl)-1H-pyrazol-4-ylamino]-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile 
• 908111-49-9 2-({2-[2-(dimethylamino)ethoxy]pyridin-4-yl}amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide 

Relevant academic research and scientific papers

Synthesis and Activity of a New Series of Antileishmanial Agents

We have determined that tetrahydroindazoles such as 1 show potent activity against Leishmania donovani, the causative agent of leishmaniasis. While the Hsp90 activity and anticancer properties of 1 have previously been explored, we present here our effort

ANTIMICROBIAL COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT OF INFECTIONS

The present disclosure provides compositions including a compound (e.g., compounds A-D), pharmaceutical compositions including the compound, methods of treatment of a condition (e.g., an infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

OMEGA-AMINO ACID DERIVATIVES OF BENZENE, PYRIDINE, AND PYRIDAZINE COMPOUNDS

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1/sub

COMPOUNDS AND METHODS

Disclosed are compounds having the formula I, wherein Ar, n, Rx, k, X, m, Z and R are as defined herein, and methods of making and using the same.

Tetrahydroindazolone substituted 2-aminobenzamides as fluorescent probes: Switching metal ion selectivity from zinc to cadmium by interchanging the amino and carbamoyl groups on the fluorophore

Three fluorescent probes CdABA′, CdABA and ZnABA′, which are structural isomers of ZnABA, have been designed with N,N-bis(2-pyridylmethyl) ethylenediamine (BPEA) as chelator and 2-aminobenzamide as fluorophore. These probes can be divided into two groups: CdABA, CdABA′ for Cd2+ and ZnABA, ZnABA′ for Zn2+. Although there is little difference in their chemical structures, the two groups of probes exhibit totally different fluorescence properties for preference of Zn2+ or Cd 2+. In the group of Zn2+ probes, ZnABA/ZnABA′ distinguish Zn2+ from Cd2+ with FZn 2+-FCd2+ = 1.87-2.00. Upon interchanging the BPEA and carbamoyl groups on the aromatic ring of the fluorophore, the structures of ZnABA/ZnABA′ are converted into CdABA/CdABA′. Interestingly, the metal ions selectivity of CdABA/CdABA′ was switched to discriminate Cd2+ from Zn2+ with FCd 2+-FZn2+ = 2.27-2.36, indicating that a small structural modification could lead to a remarkable change of the metal ion selectivity. 1H NMR titration and ESI mass experiments demonstrated that these fluorescent probers exhibited different coordination modes for Zn2+ and Cd2+. With CdABA′ as an example, generally, upon addition of Cd2+, the fluorescence response possesses PET pathway to display no obvious shift of maximum λem in the absence or presence of Cd2+. However, an ICT pathway could be employed after adding Zn2+ into the CdABA′ solution, resulting in a distinct red-shift of maximal λem. The Royal Society of Chemistry 2012.

Design and synthesis of fluorescent sensors for zinc ion derived from 2-aminobenzamide

Four novel Zn2+ fluorescent sensors have been designed with N, N-bis(2-pyridylmethyl)ethylenediamine as chelator and 2-aminobenzamide as fluorophore. These sensors were prepared in two or three steps from readily available starting materials. Of the four designed sensors, ZnABA was found to be the most efficient Zn2+-specific fluorescent probe and has good solubility in biological buffer, a large Stokes shift (186 nm), a high off-on fluorescence response (16-fold enhancement), and distinct selectivity towards Zn2+ over other metal ions. Our results have demonstrated an excellent linear relationship between the fluorescence intensity of ZnABA and the Zn2+ concentration from 0 to 10 μM, which indicates that ZnABA has the potential to be used for the quantitative determination of Zn 2+ in an aqueous environment.

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents

A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library. These indol-4-one and indazol-4-one derived 2-aminobenzamides showed strong binding affinity to Hsp

Cyclohexylamino Benzene, Pyridine, and Pyridazine Derivatives

Disclosed are compounds and pharmaceutically acceptable salts of Formula (I), wherein Q1, Q2, RN, R1, R2, R5, R6, R7, R8, X1, X2, Xsu

TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES

Disclosed are compounds and pharmaceutically acceptable salts of Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined