908140-95-4

Upstream product

• 263008-90-8 1-(4-Chlorophenyl)-4-ethoxy-1,2,5,6-tetrahydropyridine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 106-47-8 4-chloro-aniline 
• 113759-96-9 1-(4-chlorophenyl)piperidin-4-one 
• 119836-12-3 4-hydroxy-1-(4-chlorophenyl)piperidine 
• 72548-31-3 1,5-Dichloropentan-3-ol 
• 3592-25-4 1,5-dichloropentan-3-one 
• 263008-89-5 1-(4-Chlorophenyl)-4,4-diethoxypiperidine 
• 58-96-8 uridine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 

Downstream Products

• 908141-04-8 diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 908141-00-4 2'-O-[1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl]-5'-O-(4,4-dimethoxytrityl)uridine 
• 263008-94-2 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]uridine 

Relevant academic research and scientific papers

Large-scale synthesis of "Cpep" RNA monomers and their application in automated RNA synthesis

Small interfering RNAs (siRNA) are the latest candidates for oligonucleotide-based therapeutics. Should siRNA be successful in clinical trials, a huge demand for synthetic RNA is anticipated. We believe that 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.