908242-61-5Relevant articles and documents
Short syntheses of 1-substituted dibenzothiophene derivatives
Welsh, Erin N.,Robertson, Katherine N.,Speed, Alexander W. H.
supporting information, p. 2000 - 2007 (2021/03/16)
The 1-substituted dibenzothiophene motif is an unusual substitution pattern that has previously been accessedviaa multi-step synthesis. We demonstrate a simple one-pot preparation of 1-lithiodibenzothiophene from commercial materialsviaa cascade of two benzyne additions and conversion to several derivatives by addition of electrophiles. A chiral amine containing the 1-dibenzothiophene motif was also prepared. This work avoids the use of precious metals ortert-butyllithium and is much shorter and more convenient than existing routes to 1-substituted dibenzothiophenes.