908243-81-2Relevant academic research and scientific papers
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties
Doulgkeris, Christos M.,Galanakis, Dimitrios,Kourounakis, Angeliki P.,Tsiakitzis, Karyofyllis C.,Gavalas, Antonios M.,Eleftheriou, Phaedra T.,Victoratos, Panagiotis,Rekka, Eleni A.,Kourounakis, Panos N.
, p. 825 - 829 (2006)
We have designed and synthesized a series of novel molecules having a residue of a classical NSAID and an antioxidant moiety, both attached through amide bonds to a known nootropic structure, an l-proline, trans-4-hydroxy-l- proline or dl-pipecolinic acid residue. The compounds were found to retain anti-inflammatory and antioxidant activities, to acquire hypocholesterolemic action, and to possess a greatly reduced gastrointestinal toxicity. The novel molecules could find useful applications, among others, in slowing the progression or delaying the onset of neurodegenerative diseases.
