90830-64-1Relevant academic research and scientific papers
Synthesis of isotopically labeled all-trans retinals for DNP-enhanced solid-state NMR studies of retinylidene proteins
Leeder, Alexander J.,Brown, Lynda J.,Becker-Baldus, Johanna,Mehler, Michaela,Glaubitz, Clemens,Brown, Richard C.D.
, (2018)
Three all-trans retinals containing multiple 13C labels have been synthesized to enable dynamic nuclear polarization enhanced solid-state magic angle spinning NMR studies of novel microbial retinylidene membrane proteins including proteorhodpsi
Stable isotope labeled patulin and synthesis method thereof
-
Paragraph 0047; 0060-0061, (2021/06/23)
The invention discloses stable isotope labeled patulin and a synthesis method thereof. By taking stable isotope C labeled glycerol-C as an initial raw material through a terminal hydroxyl protection reaction, a reaction of oxidizing a middle hy
Synthesis of the lipid peroxidation product 4-hydroxy-2(E)-nonenal with 13C stable isotope incorporation
Jouanin,Sreevani,Rathahao,Gueraud,Paris
, p. 87 - 92 (2008/09/19)
The aim of this work was to synthesize 13C internal standards for the quantification of 4-hydroxy-2(E)-nonenal (HNE), a lipid peroxidation product, and of the etheno-adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight-step synthesis starting from ethyl 2-bromoacetate and giving access to 4-[(tetrahydro-2H-pyran-2-yl)oxy]-2(E)- nonenal. This compound is a precursor of HNE. The scheme was then used to produce the 13C precursor [1,2-13C2]-4- [(tetrahydro-2H-pyran-2-yl)oxy]-2(E)-nonenal. [1,2-13C 2]HNE was obtained by acid deprotection. All the intermediary and final compounds were fully characterized by IR, HRMS, 1H and 13C NMR. It is the first synthesis of HNE which enables the incorporation of two 13C labels at determined positions. Copyright
Synthesis of multiply 13C-labeled furofuran lignans using 13C-labeled cinnamyl alcohols as building blocks
Haajanen, Kati,Botting, Nigel P.
, p. 231 - 239 (2007/10/03)
Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of
