908368-69-4

Upstream product

• 1711-10-0 3-iodobenzoyl chloride 
• 100-66-3 methoxybenzene 
• 618-51-9 3-Iodobenzoic acid 

Downstream Products

• 908368-70-7 3-(4,8-dimethylnonyl)-4'-methoxybenzophenone 
• 1446099-51-9 (R)-(3-iodophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone 
• 1446099-61-1 (4-(3-chloropropoxy)phenyl)(3-iodophenyl)methanone 
• 1610838-90-8 (R)-(3-iodophenyl)(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)methanone 
• 1610838-88-4 (4-hydroxy-3-iodophenyl)(3-iodophenyl)methanone 
• 341989-93-3 (4-hydroxyphenyl)(3-iodophenyl)methanone 

Relevant academic research and scientific papers

Regio- And diastereoselective Pd-catalyzed synthesis of C2-aryl glycosides

An efficient regio- and diastereoselective arylation method of readily available 2,3-glycals with various aryl iodides has been established. Using the Pd(OAc)2/AsPh3 precatalytic system, this protocol proved to be general to prepare a variety of substituted C2-aryl glycosides in good yields with complete diastereoselectivity.

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

We synthesized and evaluated a series of compounds for their allosteric modulation at the Kv11.1 (hERG) channel. Most compounds were negative allosteric modulators of [3H]dofetilide binding to the channel, in particular 7f, 7h-j and 7p. Compounds 7f and 7p were the most potent negative allosteric modulators amongst all ligands, significantly increasing the dissociation rate of dofetilide in the radioligand kinetic binding assay, while remarkably reducing the affinities of dofetilide and astemizole in a competitive displacement assay. Additionally, both 7f and 7p displayed peculiar displacement characteristics with Hill coefficients significantly distinct from unity as shown by e.g., dofetilide, further indicative of their allosteric effects on dofetilide binding. Our findings in this investigation yielded several promising negative allosteric modulators for future functional and clinical research with respect to their antiarrhythmic propensities, either alone or in combination with known Kv11.1 blockers.

Synthesis and biological evaluation of XB-1 analogues as novel histamine H3 receptor antagonists and neuroprotective agents

A novel class of H3 receptor antagonists, XB-1 analogues based on benzophenone or oxydibenzene scaffolds were synthesized, and their biological activities were evaluated to determine their in vitro neuroprotective effects against Aβ25-35-induced damage in primary cortical neurons and against glutamate-induced neuronal injury in primary cerebellar granule neurons. The results indicated that all of the tested analogues displayed neuroprotective activity at 0.1 μM or 1 μM. These findings may provide new insights into the development of novel promising H3 receptor antagonists with potential neuroprotective activity.

Nonsteroidal benzophenone-containing analogues of cholesterol

The four benzophenones, 10-13, containing the natural side chain of cholesterol (1) have been synthesized to explore whether the tetracyclic nucleus of 1 is essential for its biochemical properties. The syntheses of analogues 10, 11, and 13 feature efficient introduction of the alkyl side chain by Suzuki coupling. Preliminary biochemical evaluation of 10 and 12 suggests that the sterol tetracyclic nucleus is not required for biological compatibility with 1.