90840-54-3

Upstream product

• 1225387-53-0 3⁽⁵⁾-aminopyrazole 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 

Downstream Products

• 148191-54-2 pyrazolo<1,5-a>pyrido<3,4-e>pyrimidin-6(7H)-one 
• 1370287-72-1 7-methyl-N-(2-phenoxyethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide 
• 1370287-71-0 3-(3,4-dichlorophenyl)-7-methyl-N-(2-phenoxyethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide 
• 924567-37-3 3-(3-chlorophenyl)-7-methyl-N-(2-phenoxyethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide 
• 1370287-70-9 3-(4-chlorophenyl)-7-methyl-N-(2-phenoxyethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide 
• 1370287-43-6 ethyl 3-bromo-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate 

Relevant academic research and scientific papers

Novel 3,6,7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A)

A number of pyrazolopyrimidines were synthesized and tested for their positive allosteric modulation of the HCA2 receptor (GPR109A). Compound 24, an efficacious and potent agonist and allosteric enhancer of nicotinic acid's action, was the basis for most other compounds. Interestingly, some of the compounds were found to increase the efficacy of the endogenous ligand 3-hydroxybutyrate and enhance its potency almost 10-fold. This suggests that the pyrazolopyrimidines may have therapeutic value when given alone.

Reactivity of 7-(2-Dimethylaminovinyl)pyrazolopyrimidines: Synthesis of Pyrazolopyridopyrimidine Derivatives as Potential Benzodiazepine Receptor Ligands. 2.

A series of pyrazolopyridopyrimidin-6-ones was obtained by reaction of ammonium acetate with ethyl 7-dimethylaminovinylpyrazolopyrimidine-6-carboxylates and these had been prepared from ethyl 7-methylpyrazolopyrimidine-6-carboxylates by reaction with dimethylformamide dimethylacetat.Under these conditions the compounds bearing a 2-hydroxy group were also O-alkylated.During the preparation of the ethyl 2-hydroxy-7-methyl-3-phenylpyrazolopyrimidine-6-carboxylate the corresponding 5-methyl isomer was isolated and identified.

Unambiguous Structure Determination of Some Pyrazolopyrimidine Derivatives by Multinuclear NMR Spectroscopy

The condensation of 3(5)-aminopyrazole and 5-amino-3-phenylpyrazole with ethyl 2,4-dioxopentanoate and 2-ethoxymethylidene-3-oxobutyrate has been re-investigated.Contrary to previous reports, the former reaction gives rise to both regioisomeric pyrazolo1