908598-98-1

Upstream product

• 100-39-0 benzyl bromide 

Downstream Products

• 1212293-24-7 (R)-1-Benzyl-pyrrolidine-3-carboxylic acid; hydrochloride 
• 216311-63-6 2-((S)-1-Benzyl-pyrrolidin-3-yl)-malonic acid diethyl ester 
• 216311-65-8 Ethyl (3S)-2-(1-benzylpyrrolidin-3-yl)acetate 
• 216311-67-0 (3S)-2-(1-Benzylpyrrolidin-3-yl)acetic acid 
• 216311-59-0 methyl (R)-(-)-1-(phenylmethyl)-3-pyrrolidinecarboxylate 
• 118354-71-5 (S)-methanesulfonic acid 1-benzylpyrrolidin-3-yl ester 
• 157528-56-8 (R)-1-benzylpyrrolidine-3-carbonitrile 
• 309912-53-6 (3R)-methanesulfonic acid 4-phthalimido-3-(N,N-dibenzylamino)butyl ester 
• 309912-54-7 (4R)-4-(N,N-dibenzylamino)-5-phthalimidopentanenitrile 
• 309912-49-0 (3S,4R)-1-benzyl-4-(N,N-dibenzylamino)-3-methylpiperidin-2-one 
• 309912-75-2 (4R)-4-(N,N-dibenzylamino-2-oxopiperidin-1-yl)acetic acid ethyl ester 
• 309912-46-7 (4R)-1-benzyl-4-(N,N-dibenzylamino)piperidin-2-one 
• 309912-45-6 (4R)-4-(N,N-dibenzylamino)-2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 309912-61-6 (5R)-1-benzyl-5-(N,N-dibenzylamino)-piperidin-2-one 

Relevant academic research and scientific papers

Exploration of a new type of antimalarial compounds based on febrifugine

Febrifugine (1), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. The use of 1 as an antimalarial drug has been precluded because of side effects, such as diarrhea, vomiting

A practical ex-chiral-pool synthesis of β-proline and homo-β-proline

Starting from aspartic acid an efficient synthesis of enantiomerically pure β-proline and homo-β-proline is described. The key step of the synthesis includes formation of the 1,4-biselectrophile 6, followed by rearrangement via the aziridinium intermediate 7 and ring closure to give the pyrrolidinium salt 9a which can serve as a common precursor for both target compounds.