90870-20-5

Usage

Uses

Used in Organic Synthesis:
N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows it to be a key component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate's reactivity and functional groups enable it to participate in a range of chemical reactions, facilitating the creation of complex molecules with specific properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate is utilized as a building block in the development of new drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties, such as potency, selectivity, and bioavailability. Researchers and chemists leverage the compound's characteristics to design and synthesize novel therapeutic agents that address unmet medical needs.
Used in Agrochemical Development:
N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate also finds application in the agrochemical sector, where it serves as a precursor in the synthesis of pesticides and other crop protection agents. Its role in these formulations can enhance the effectiveness of the final product, ensuring better pest control and crop yield.
Used in Specialty Chemicals Production:
Beyond the pharmaceutical and agrochemical industries, N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate is employed in the production of specialty chemicals. These can include dyes, fragrances, and other high-value compounds that are used across various industries, such as cosmetics, textiles, and food additives. The versatility of N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate allows it to be a crucial component in the synthesis of these diverse products.

Upstream product

• 91980-75-5 N-methylethylamine hydroiodide 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 624-78-2 N-Ethylmethylamine 

Downstream Products

• 727418-36-2 rivastigmine hydrochloride 
• 105601-20-5 rac-rivastigmine 

Relevant academic research and scientific papers

17(R),18(S)-Epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: Structure-activity relationships and stable analogues

17(R),18(S)-Epoxyeicosatetraenoic acid [17(R),18(S)-EETeTr], a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (EPA), exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca 2+-overload with EC50 ≈ 1-2 nM. Structure-activity studies revealed that a cis-Δ11,12- or Δ14,15- olefin and a 17(R),18(S)-epoxide are minimal structural elements for antiarrhythmic activity whereas antagonist activity was often associated with the combination of a Δ14,15-olefin and a 17(S),18(R)-epoxide. Compared with natural material, the agonist and antagonist analogues are chemically and metabolically more robust and several show promise as templates for future development of clinical candidates.

Novel eicosanoid derivatives

The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

A PROCESS FOR THE PREPARATION OF PHENYLCARBAMATES

A process for the preparation of compound of formula (I); wherein R is hydrogen, linear, branched or cyclic lower alkyl, cyclohexyl, allyl, propargyl or benzyl; R is hydrogen, methyl, ethyl or propyl; or R and R together with the nitrogen to which they are attached form a cyclic moiety of three to eight-membered ring, with or without a hetero atom like nitrogen or oxygen; R is hydrogen or lower alkyl; R and R are the same or different and each is a lower alkyl; comprising reacting compound of formula (II); wherein R, R and R are as defined above, with compound of formula (III); wherein Rand R are as defined above, in the presence of a base, and further resolving the compound of formula (I) to obtain (S)-isomer of compound of formula (I), substantially free of R-isomer.